Risk of infections in patients with gout: a population-based cohort study

Abstract To investigate the risk of various types of infections (pneumonia and urinary tract infection (UTI)), and infection-related mortality in patients with gout compared with population-based controls. A retrospective cohort study was conducted using data from the UK Clinical Practice Research D...

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Autores principales:	B. Spaetgens, F. de Vries, J. H. M. Driessen, H. G. Leufkens, P. C. Souverein, A. Boonen, J. W. M. van der Meer, L. A. B. Joosten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64a0bd9de8ec464d91a90a6c58524434
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spelling	oai:doaj.org-article:64a0bd9de8ec464d91a90a6c585244342021-12-02T16:08:00ZRisk of infections in patients with gout: a population-based cohort study10.1038/s41598-017-01588-52045-2322https://doaj.org/article/64a0bd9de8ec464d91a90a6c585244342017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01588-5https://doaj.org/toc/2045-2322Abstract To investigate the risk of various types of infections (pneumonia and urinary tract infection (UTI)), and infection-related mortality in patients with gout compared with population-based controls. A retrospective cohort study was conducted using data from the UK Clinical Practice Research Datalink (CPRD). All patients with a first diagnosis of gout and aged >40 years between January 1987-July 2014, were included and matched with up to two controls. Time-varying Cox proportional hazards models were used to estimate the risk of infections and mortality. 131,565 patients and 252,763 controls (mean age: 64 years, 74% males, mean follow-up of 6.7 years) were included in the full cohort. After full statistical adjustment, the risk of pneumonia was increased (adj. HR 1.27, 95% CI 1.18 to 1.36), while the risk of UTI (adj. HR 0.99, 95% CI 0.97 to 1.01) was similar in patients compared to controls. No differences between patients and controls were observed for infection-related mortality due to pneumonia (adj. HR 1.03, 95% CI 0.93 to 1.14) or UTI (adj. HR 1.16, 95% CI 0.98 to 1.37). In conclusion, patients with gout did not have decreased risks of pneumonia, UTI or infection-related mortality compared to population-based controls.B. SpaetgensF. de VriesJ. H. M. DriessenH. G. LeufkensP. C. SouvereinA. BoonenJ. W. M. van der MeerL. A. B. JoostenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Spaetgens F. de Vries J. H. M. Driessen H. G. Leufkens P. C. Souverein A. Boonen J. W. M. van der Meer L. A. B. Joosten Risk of infections in patients with gout: a population-based cohort study
description	Abstract To investigate the risk of various types of infections (pneumonia and urinary tract infection (UTI)), and infection-related mortality in patients with gout compared with population-based controls. A retrospective cohort study was conducted using data from the UK Clinical Practice Research Datalink (CPRD). All patients with a first diagnosis of gout and aged >40 years between January 1987-July 2014, were included and matched with up to two controls. Time-varying Cox proportional hazards models were used to estimate the risk of infections and mortality. 131,565 patients and 252,763 controls (mean age: 64 years, 74% males, mean follow-up of 6.7 years) were included in the full cohort. After full statistical adjustment, the risk of pneumonia was increased (adj. HR 1.27, 95% CI 1.18 to 1.36), while the risk of UTI (adj. HR 0.99, 95% CI 0.97 to 1.01) was similar in patients compared to controls. No differences between patients and controls were observed for infection-related mortality due to pneumonia (adj. HR 1.03, 95% CI 0.93 to 1.14) or UTI (adj. HR 1.16, 95% CI 0.98 to 1.37). In conclusion, patients with gout did not have decreased risks of pneumonia, UTI or infection-related mortality compared to population-based controls.
format	article
author	B. Spaetgens F. de Vries J. H. M. Driessen H. G. Leufkens P. C. Souverein A. Boonen J. W. M. van der Meer L. A. B. Joosten
author_facet	B. Spaetgens F. de Vries J. H. M. Driessen H. G. Leufkens P. C. Souverein A. Boonen J. W. M. van der Meer L. A. B. Joosten
author_sort	B. Spaetgens
title	Risk of infections in patients with gout: a population-based cohort study
title_short	Risk of infections in patients with gout: a population-based cohort study
title_full	Risk of infections in patients with gout: a population-based cohort study
title_fullStr	Risk of infections in patients with gout: a population-based cohort study
title_full_unstemmed	Risk of infections in patients with gout: a population-based cohort study
title_sort	risk of infections in patients with gout: a population-based cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/64a0bd9de8ec464d91a90a6c58524434
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Risk of infections in patients with gout: a population-based cohort study

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