Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated. Here, a case of sporadic BCC in an 80-year-old man is presented, and the effectiveness of SMO inhibitors in case of relapse...

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Autor principal:	Tomoaki Takada
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	basal cell carcinoma glioma-associated oncogene 1 smoothened insulin-like growth factor 2 mrna-binding protein 1 Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/64a11ad4115b41b7b34b9b78781eb52b
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spelling	oai:doaj.org-article:64a11ad4115b41b7b34b9b78781eb52b2021-12-02T12:40:22ZActivation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma1662-656710.1159/000520256https://doaj.org/article/64a11ad4115b41b7b34b9b78781eb52b2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520256https://doaj.org/toc/1662-6567In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated. Here, a case of sporadic BCC in an 80-year-old man is presented, and the effectiveness of SMO inhibitors in case of relapse is predicted. The aim of this study was to determine whether the SMO inhibitors can be effective in treating this individual should the tumor recur in the future. Immunohistochemistry (IHC) was performed in a tumor and the adjacent skin tissue from the patient. IHC within the same BCC tissue specimen revealed that Glioma-associated oncogene 1 (GLI1) and Smoothened (SMO) in the Hh signaling pathway and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the Wnt signaling pathway were overexpressed. Hh and Wnt signaling pathways were activated. These findings suggest that the patient might be resistant to treatment with SMO inhibitors because of the interaction between Hh and Wnt signaling pathways. Overexpression of GLI1 leads to transcriptional activation, making it an attractive molecular target for anticancer therapy owing to the downstream effectors of the cascade.Tomoaki TakadaKarger Publishersarticlebasal cell carcinomaglioma-associated oncogene 1smoothenedinsulin-like growth factor 2 mrna-binding protein 1DermatologyRL1-803ENCase Reports in Dermatology, Vol 13, Iss 3, Pp 506-512 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal cell carcinoma glioma-associated oncogene 1 smoothened insulin-like growth factor 2 mrna-binding protein 1 Dermatology RL1-803
spellingShingle	basal cell carcinoma glioma-associated oncogene 1 smoothened insulin-like growth factor 2 mrna-binding protein 1 Dermatology RL1-803 Tomoaki Takada Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
description	In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated. Here, a case of sporadic BCC in an 80-year-old man is presented, and the effectiveness of SMO inhibitors in case of relapse is predicted. The aim of this study was to determine whether the SMO inhibitors can be effective in treating this individual should the tumor recur in the future. Immunohistochemistry (IHC) was performed in a tumor and the adjacent skin tissue from the patient. IHC within the same BCC tissue specimen revealed that Glioma-associated oncogene 1 (GLI1) and Smoothened (SMO) in the Hh signaling pathway and insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the Wnt signaling pathway were overexpressed. Hh and Wnt signaling pathways were activated. These findings suggest that the patient might be resistant to treatment with SMO inhibitors because of the interaction between Hh and Wnt signaling pathways. Overexpression of GLI1 leads to transcriptional activation, making it an attractive molecular target for anticancer therapy owing to the downstream effectors of the cascade.
format	article
author	Tomoaki Takada
author_facet	Tomoaki Takada
author_sort	Tomoaki Takada
title	Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
title_short	Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
title_full	Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
title_fullStr	Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
title_full_unstemmed	Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
title_sort	activation of the hedgehog and wnt/β-catenin signaling pathways in basal cell carcinoma
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/64a11ad4115b41b7b34b9b78781eb52b
work_keys_str_mv	AT tomoakitakada activationofthehedgehogandwntbcateninsignalingpathwaysinbasalcellcarcinoma
_version_	1718393740961251328

Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma

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