Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization

KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylation

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Autores principales:	Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe
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spelling	oai:doaj.org-article:64a6612989c448e0aa3b7aff1d6e39fe2021-12-02T17:26:56ZLiquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization10.1038/s41467-021-25761-72041-1723https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25761-7https://doaj.org/toc/2041-1723KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylationRajesh SharmaKyoung-Jae ChoiMy Diem QuanSonum SharmaBanumathi SankaranHyekyung ParkAnel LaGroneJean J. KimKevin R. MacKenzieAllan Chris M. FerreonChoel KimJosephine C. FerreonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajesh Sharma Kyoung-Jae Choi My Diem Quan Sonum Sharma Banumathi Sankaran Hyekyung Park Anel LaGrone Jean J. Kim Kevin R. MacKenzie Allan Chris M. Ferreon Choel Kim Josephine C. Ferreon Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
description	KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylation
format	article
author	Rajesh Sharma Kyoung-Jae Choi My Diem Quan Sonum Sharma Banumathi Sankaran Hyekyung Park Anel LaGrone Jean J. Kim Kevin R. MacKenzie Allan Chris M. Ferreon Choel Kim Josephine C. Ferreon
author_facet	Rajesh Sharma Kyoung-Jae Choi My Diem Quan Sonum Sharma Banumathi Sankaran Hyekyung Park Anel LaGrone Jean J. Kim Kevin R. MacKenzie Allan Chris M. Ferreon Choel Kim Josephine C. Ferreon
author_sort	Rajesh Sharma
title	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
title_short	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
title_full	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
title_fullStr	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
title_full_unstemmed	Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization
title_sort	liquid condensation of reprogramming factor klf4 with dna provides a mechanism for chromatin organization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64a6612989c448e0aa3b7aff1d6e39fe
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Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization

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