Identification of a cluster of HIV-1 controllers infected with low replicating viruses.
Long term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohor...
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oai:doaj.org-article:64aa2ab0fbf44fa983e5c624581910df2021-11-18T08:49:00ZIdentification of a cluster of HIV-1 controllers infected with low replicating viruses.1932-620310.1371/journal.pone.0077663https://doaj.org/article/64aa2ab0fbf44fa983e5c624581910df2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24204910/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Long term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohort identified a cluster of 6 HIV-1 controllers infected with closely-related viruses. The patients of the cluster showed common clinical and epidemiological features: drug user practices, infection in the same city (Madrid, Spain) and at the same time (late 70's-early 80's). All cluster patients displayed distinct host alleles associated with HIV control. Analysis of the virus envelope nucleotide sequences showed ancestral characteristic, lack of evolution and presence of rare amino-acids. Biological characterization of recombinant viruses with the envelope proteins from the cluster viruses showed very low replicative capacity in TZMbl and U87-CD4/CCR5 cells. The lack of clinical progression in the viral cluster patients with distinct combinations of protective host genotypes, but infected by low replicating viruses, indicate the important role of the virus in the non-progressor phenotype in these patients.Concepción CasadoMaria PernasVirginia SandonisTamara Alvaro-CifuentesIsabel OlivaresRosa FuentesLorena Martínez-PratsEulalia GrauLidia RuizRafael DelgadoCarmen RodríguezJorge del RomeroCecilio López-GalíndezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e77663 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Concepción Casado Maria Pernas Virginia Sandonis Tamara Alvaro-Cifuentes Isabel Olivares Rosa Fuentes Lorena Martínez-Prats Eulalia Grau Lidia Ruiz Rafael Delgado Carmen Rodríguez Jorge del Romero Cecilio López-Galíndez Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| description |
Long term non-progressor patients (LTNPs) are characterized by the natural control of HIV-1 infection. This control is related to host genetic, immunological and virological factors. In this work, phylogenetic analysis of the proviral nucleotide sequences in env gene from a Spanish HIV-1 LTNPs cohort identified a cluster of 6 HIV-1 controllers infected with closely-related viruses. The patients of the cluster showed common clinical and epidemiological features: drug user practices, infection in the same city (Madrid, Spain) and at the same time (late 70's-early 80's). All cluster patients displayed distinct host alleles associated with HIV control. Analysis of the virus envelope nucleotide sequences showed ancestral characteristic, lack of evolution and presence of rare amino-acids. Biological characterization of recombinant viruses with the envelope proteins from the cluster viruses showed very low replicative capacity in TZMbl and U87-CD4/CCR5 cells. The lack of clinical progression in the viral cluster patients with distinct combinations of protective host genotypes, but infected by low replicating viruses, indicate the important role of the virus in the non-progressor phenotype in these patients. |
| format |
article |
| author |
Concepción Casado Maria Pernas Virginia Sandonis Tamara Alvaro-Cifuentes Isabel Olivares Rosa Fuentes Lorena Martínez-Prats Eulalia Grau Lidia Ruiz Rafael Delgado Carmen Rodríguez Jorge del Romero Cecilio López-Galíndez |
| author_facet |
Concepción Casado Maria Pernas Virginia Sandonis Tamara Alvaro-Cifuentes Isabel Olivares Rosa Fuentes Lorena Martínez-Prats Eulalia Grau Lidia Ruiz Rafael Delgado Carmen Rodríguez Jorge del Romero Cecilio López-Galíndez |
| author_sort |
Concepción Casado |
| title |
Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| title_short |
Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| title_full |
Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| title_fullStr |
Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| title_full_unstemmed |
Identification of a cluster of HIV-1 controllers infected with low replicating viruses. |
| title_sort |
identification of a cluster of hiv-1 controllers infected with low replicating viruses. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/64aa2ab0fbf44fa983e5c624581910df |
| work_keys_str_mv |
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| _version_ |
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