Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Summary: Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and distributed readily to treat patients are necessary. Invariant natural killer T (iNKT) cells are ideal cell carriers for developing allogenei...

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Bibliographic Details
Main Authors: Yan-Ruide Li, Yang Zhou, Yu Jeong Kim, Yanni Zhu, Feiyang Ma, Jiaji Yu, Yu-Chen Wang, Xianhui Chen, Zhe Li, Samuel Zeng, Xi Wang, Derek Lee, Josh Ku, Tasha Tsao, Christian Hardoy, Jie Huang, Donghui Cheng, Amélie Montel-Hagen, Christopher S. Seet, Gay M. Crooks, Sarah M. Larson, Joshua P. Sasine, Xiaoyan Wang, Matteo Pellegrini, Antoni Ribas, Donald B. Kohn, Owen Witte, Pin Wang, Lili Yang
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
hematopoietic stem cell
invariant natural killer T cells
cancer immunotherapy
allogeneic off-the-shelf cell therapy
chimeric antigen receptor
allogeneic HSC-engineered iNKT cells
Medicine (General)
R5-920
Online Access:https://doaj.org/article/64abb953f8fd44bf8d0230b66356f289
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https://doaj.org/article/64abb953f8fd44bf8d0230b66356f289

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