Walking impairment in patients with multiple sclerosis: exercise training as a treatment option

Robert W Motl1, Myla D Goldman2, Ralph HB Benedict31Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2Department of Neurology, University of Virginia, VA, USA; 3Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USAAbstr...

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Autores principales:	Robert W Motl, Myla D Goldman, Ralph HB Benedict
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/64af203789d14bf598de01dab6724527
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spelling	oai:doaj.org-article:64af203789d14bf598de01dab67245272021-12-02T01:34:33ZWalking impairment in patients with multiple sclerosis: exercise training as a treatment option1176-63281178-2021https://doaj.org/article/64af203789d14bf598de01dab67245272010-11-01T00:00:00Zhttp://www.dovepress.com/walking-impairment-in-patients-with-multiple-sclerosis-exercise-traini-a5658https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Robert W Motl1, Myla D Goldman2, Ralph HB Benedict31Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2Department of Neurology, University of Virginia, VA, USA; 3Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USAAbstract: Multiple sclerosis (MS) is a chronic disease of the central nervous system that culminates in the progression of physical and cognitive disability over time. Walking impairment is a ubiquitous feature of MS and a sentinel characteristic of the later or advanced stages of the disease. This paper presents a conceptual rationale along with empirical evidence for exercise training as a rehabilitation approach for managing walking impairment and improving walking function in persons with MS. Conceptually, MS is associated with a decrease in physical activity, which, in turn, can result in deconditioning across multiple domains of physiological functioning. The resulting deconditioning feeds back and further drives physical inactivity until a threshold is reached that likely initiates the progression of walking impairment in MS. Empirically, physical activity and exercise training have been associated with beneficial effects on walking function in persons with MS. This is based on cross-sectional, longitudinal, and experimental research that included diversity in the breadth of measures of walking, persons with MS, and exercise/physical activity characteristics. Of particular importance, future researchers might consider examining the combinatory effects of exercise training plus pharmacological agents on walking mobility in MS. Collectively, exercise training and physical activity might hold significant potential for the management of progressive mobility disability in MS.Keywords: mobility, walking, exercise, physical activity, movement Robert W MotlMyla D GoldmanRalph HB BenedictDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 767-774 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Robert W Motl Myla D Goldman Ralph HB Benedict Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
description	Robert W Motl1, Myla D Goldman2, Ralph HB Benedict31Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA; 2Department of Neurology, University of Virginia, VA, USA; 3Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USAAbstract: Multiple sclerosis (MS) is a chronic disease of the central nervous system that culminates in the progression of physical and cognitive disability over time. Walking impairment is a ubiquitous feature of MS and a sentinel characteristic of the later or advanced stages of the disease. This paper presents a conceptual rationale along with empirical evidence for exercise training as a rehabilitation approach for managing walking impairment and improving walking function in persons with MS. Conceptually, MS is associated with a decrease in physical activity, which, in turn, can result in deconditioning across multiple domains of physiological functioning. The resulting deconditioning feeds back and further drives physical inactivity until a threshold is reached that likely initiates the progression of walking impairment in MS. Empirically, physical activity and exercise training have been associated with beneficial effects on walking function in persons with MS. This is based on cross-sectional, longitudinal, and experimental research that included diversity in the breadth of measures of walking, persons with MS, and exercise/physical activity characteristics. Of particular importance, future researchers might consider examining the combinatory effects of exercise training plus pharmacological agents on walking mobility in MS. Collectively, exercise training and physical activity might hold significant potential for the management of progressive mobility disability in MS.Keywords: mobility, walking, exercise, physical activity, movement
format	article
author	Robert W Motl Myla D Goldman Ralph HB Benedict
author_facet	Robert W Motl Myla D Goldman Ralph HB Benedict
author_sort	Robert W Motl
title	Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
title_short	Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
title_full	Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
title_fullStr	Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
title_full_unstemmed	Walking impairment in patients with multiple sclerosis: exercise training as a treatment option
title_sort	walking impairment in patients with multiple sclerosis: exercise training as a treatment option
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/64af203789d14bf598de01dab6724527
work_keys_str_mv	AT robertwmotl walkingimpairmentinpatientswithmultiplesclerosisexercisetrainingasatreatmentoption AT myladgoldman walkingimpairmentinpatientswithmultiplesclerosisexercisetrainingasatreatmentoption AT ralphhbbenedict walkingimpairmentinpatientswithmultiplesclerosisexercisetrainingasatreatmentoption
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Walking impairment in patients with multiple sclerosis: exercise training as a treatment option

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