Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients

Abstract Common variable immunodeficiency (CVID) is a complex primary immunodeficiency disorder characterized by a high clinical and genetic heterogeneity. The molecular underlying causes of CVID are not still now clear and the delays in diagnosis and treatment worsen the prognosis of the patients....

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Autores principales:	Bruna De Felice, Ersilia Nigro, Rita Polito, Francesca Wanda Rossi, Antonio Pecoraro, Giuseppe Spadaro, Aurora Daniele
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64b0013bf6a140c3a349c6b6530911ac
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spelling	oai:doaj.org-article:64b0013bf6a140c3a349c6b6530911ac2021-12-02T15:11:53ZDifferently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients10.1038/s41598-020-77100-32045-2322https://doaj.org/article/64b0013bf6a140c3a349c6b6530911ac2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77100-3https://doaj.org/toc/2045-2322Abstract Common variable immunodeficiency (CVID) is a complex primary immunodeficiency disorder characterized by a high clinical and genetic heterogeneity. The molecular underlying causes of CVID are not still now clear and the delays in diagnosis and treatment worsen the prognosis of the patients. MicroRNAs are non-coding, endogenous small RNAs often deregulated in human diseases, such as autoimmune and other immune-based disorders. In the present study, we aimed to evaluate miRNAs associated with the CVID and, in particular, with the response to the first Ig replacement therapy. To this aim, we compared miRNA profile obtained by serum samples of treatment-naïve CVID patients before and 24 h after the first Ig replacement therapy. For the first time, using a microarray assay followed by an integrated bioinformatics/biostatistics analysis, we identified five microRNAs (hsa-miR-6742, hsa-miR-1825, hsa-miR-4769-3p, hsa-miR-1228-3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. All of them were down-regulated, excepted miR-6742 which was up-regulated. The latter may be of particular interest, since its functions are related to pathways involving Class I MHC mediated antigen processing and adaptive as well as innate Immune System. In conclusion, this study shows for the first time the modulation of miRNAs involved in CVID patients after the first Ig replacement therapy. Further studies are needed to assess whether such miRNAs could represent novel potential biomarkers in management and therapy of CVID patients.Bruna De FeliceErsilia NigroRita PolitoFrancesca Wanda RossiAntonio PecoraroGiuseppe SpadaroAurora DanieleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruna De Felice Ersilia Nigro Rita Polito Francesca Wanda Rossi Antonio Pecoraro Giuseppe Spadaro Aurora Daniele Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
description	Abstract Common variable immunodeficiency (CVID) is a complex primary immunodeficiency disorder characterized by a high clinical and genetic heterogeneity. The molecular underlying causes of CVID are not still now clear and the delays in diagnosis and treatment worsen the prognosis of the patients. MicroRNAs are non-coding, endogenous small RNAs often deregulated in human diseases, such as autoimmune and other immune-based disorders. In the present study, we aimed to evaluate miRNAs associated with the CVID and, in particular, with the response to the first Ig replacement therapy. To this aim, we compared miRNA profile obtained by serum samples of treatment-naïve CVID patients before and 24 h after the first Ig replacement therapy. For the first time, using a microarray assay followed by an integrated bioinformatics/biostatistics analysis, we identified five microRNAs (hsa-miR-6742, hsa-miR-1825, hsa-miR-4769-3p, hsa-miR-1228-3p, hsa-miR-1972) differently modulated in CVID patients by Ig infusion. All of them were down-regulated, excepted miR-6742 which was up-regulated. The latter may be of particular interest, since its functions are related to pathways involving Class I MHC mediated antigen processing and adaptive as well as innate Immune System. In conclusion, this study shows for the first time the modulation of miRNAs involved in CVID patients after the first Ig replacement therapy. Further studies are needed to assess whether such miRNAs could represent novel potential biomarkers in management and therapy of CVID patients.
format	article
author	Bruna De Felice Ersilia Nigro Rita Polito Francesca Wanda Rossi Antonio Pecoraro Giuseppe Spadaro Aurora Daniele
author_facet	Bruna De Felice Ersilia Nigro Rita Polito Francesca Wanda Rossi Antonio Pecoraro Giuseppe Spadaro Aurora Daniele
author_sort	Bruna De Felice
title	Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
title_short	Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
title_full	Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
title_fullStr	Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
title_full_unstemmed	Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients
title_sort	differently expressed microrna in response to the first ig replacement therapy in common variable immunodeficiency patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/64b0013bf6a140c3a349c6b6530911ac
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Differently expressed microRNA in response to the first Ig replacement therapy in common variable immunodeficiency patients

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