IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tum...

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Autores principales:	Irini Evnouchidou, Pascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A. Gross, Loredana Saveanu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64b251bfea0c4668a8923bf82ed550e8
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spelling	oai:doaj.org-article:64b251bfea0c4668a8923bf82ed550e82021-12-02T15:56:47ZIRAP-dependent endosomal T cell receptor signalling is essential for T cell responses10.1038/s41467-020-16471-72041-1723https://doaj.org/article/64b251bfea0c4668a8923bf82ed550e82020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16471-7https://doaj.org/toc/2041-1723T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.Irini EvnouchidouPascal ChappertSamira BenaddaAndres ZucchettiMirjana WeimershausMarcelle BensVivien CaillensDespoina KoumantouSophie LotersztajnPeter van EndertJean DavoustPierre GuermonprezClaire HivrozDavid A. GrossLoredana SaveanuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
description	T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is shown by the absence of efficient polyclonal anti-tumour response in mice with T-specific conditional deletion of IRAP.
format	article
author	Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu
author_facet	Irini Evnouchidou Pascal Chappert Samira Benadda Andres Zucchetti Mirjana Weimershaus Marcelle Bens Vivien Caillens Despoina Koumantou Sophie Lotersztajn Peter van Endert Jean Davoust Pierre Guermonprez Claire Hivroz David A. Gross Loredana Saveanu
author_sort	Irini Evnouchidou
title	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
title_short	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
title_full	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
title_fullStr	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
title_full_unstemmed	IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
title_sort	irap-dependent endosomal t cell receptor signalling is essential for t cell responses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/64b251bfea0c4668a8923bf82ed550e8
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IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

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