Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

Abstract Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing th...

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Autores principales:	Ana Amorim-de-Sousa, Tim Schilling, Paulo Fernandes, Yeshwanth Seshadri, Hamed Bahmani, José Manuel González-Méijome
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64b3081edd9043fc93387bd424302b41
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spelling	oai:doaj.org-article:64b3081edd9043fc93387bd424302b412021-12-02T16:55:46ZBlue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes10.1038/s41598-021-88459-22045-2322https://doaj.org/article/64b3081edd9043fc93387bd424302b412021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88459-2https://doaj.org/toc/2045-2322Abstract Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.Ana Amorim-de-SousaTim SchillingPaulo FernandesYeshwanth SeshadriHamed BahmaniJosé Manuel González-MéijomeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Amorim-de-Sousa Tim Schilling Paulo Fernandes Yeshwanth Seshadri Hamed Bahmani José Manuel González-Méijome Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
description	Abstract Upregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.
format	article
author	Ana Amorim-de-Sousa Tim Schilling Paulo Fernandes Yeshwanth Seshadri Hamed Bahmani José Manuel González-Méijome
author_facet	Ana Amorim-de-Sousa Tim Schilling Paulo Fernandes Yeshwanth Seshadri Hamed Bahmani José Manuel González-Méijome
author_sort	Ana Amorim-de-Sousa
title	Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
title_short	Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
title_full	Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
title_fullStr	Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
title_full_unstemmed	Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes
title_sort	blue light blind-spot stimulation upregulates b-wave and pattern erg activity in myopes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64b3081edd9043fc93387bd424302b41
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Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

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