Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats

The current study was aimed to analyze the therapeutic effect of selected medicinal plants, that is, Curcuma longa, Zingiber officinale, Trigonella graceum-foenum, Nigella sativa, and Syzygium aromaticum against carrageenan-induced oxidative stress and inflammation in rats. Phytochemical analysis re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hina Fatima, Muhammad Shahid, Amer Jamil, Muhammad Naveed
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/64b74198800341b88a2522e748a2f083
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64b74198800341b88a2522e748a2f083
record_format	dspace
spelling	oai:doaj.org-article:64b74198800341b88a2522e748a2f0832021-12-01T23:35:26ZTherapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats1559-325810.1177/15593258211058028https://doaj.org/article/64b74198800341b88a2522e748a2f0832021-11-01T00:00:00Zhttps://doi.org/10.1177/15593258211058028https://doaj.org/toc/1559-3258The current study was aimed to analyze the therapeutic effect of selected medicinal plants, that is, Curcuma longa, Zingiber officinale, Trigonella graceum-foenum, Nigella sativa, and Syzygium aromaticum against carrageenan-induced oxidative stress and inflammation in rats. Phytochemical analysis revealed the presence of diverse range of bioactives. IC 50 values for antioxidant assays including DPPH (2,2-diphenyl-1-picrylhydrazyl), metal chelating, ABTS scavenging (2, 2 ′ -Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid), β-carotene bleaching, and H 2 O 2 (hydrogen peroxide) scavenging ranged from 37-294, 71-243.4, 69.66-191.8, 98.92-228.5, and 82-234.9 μg/mL, respectively. All tested plants extract were found active against tested pathogenic microorganisms with lowest minimum inhibitory concentrations. Oral administration of tested plants extracts in different doses (250, 500, and 1000 mg/kg b. w) did not exhibit any toxicological effects on hemato-biochemical profile of treated rats in comparison to control group rats. Further, plants extract exhibited considerable anti-inflammatory activity in rats paw inflammation and decreased cellular infiltration to inflammatory site in dose dependent manner. Pretreatment of animals with tested plants extract (100, 200, and 400 mg/kg b. w.) caused significant alteration in total antioxidants, oxidants, and enzymes activities in paw tissue homogenate and the effect was more pronounced at higher concentration (400 mg/kg b. w.). Results showed that tested plants extract are rich source of diverse classes of phenolics and have therapeutic potential against oxidative stress and inflammation.Hina FatimaMuhammad ShahidAmer JamilMuhammad NaveedSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENDose-Response, Vol 19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Hina Fatima Muhammad Shahid Amer Jamil Muhammad Naveed Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
description	The current study was aimed to analyze the therapeutic effect of selected medicinal plants, that is, Curcuma longa, Zingiber officinale, Trigonella graceum-foenum, Nigella sativa, and Syzygium aromaticum against carrageenan-induced oxidative stress and inflammation in rats. Phytochemical analysis revealed the presence of diverse range of bioactives. IC 50 values for antioxidant assays including DPPH (2,2-diphenyl-1-picrylhydrazyl), metal chelating, ABTS scavenging (2, 2 ′ -Azino-Bis-3-Ethylbenzothiazoline-6-Sulfonic Acid), β-carotene bleaching, and H 2 O 2 (hydrogen peroxide) scavenging ranged from 37-294, 71-243.4, 69.66-191.8, 98.92-228.5, and 82-234.9 μg/mL, respectively. All tested plants extract were found active against tested pathogenic microorganisms with lowest minimum inhibitory concentrations. Oral administration of tested plants extracts in different doses (250, 500, and 1000 mg/kg b. w) did not exhibit any toxicological effects on hemato-biochemical profile of treated rats in comparison to control group rats. Further, plants extract exhibited considerable anti-inflammatory activity in rats paw inflammation and decreased cellular infiltration to inflammatory site in dose dependent manner. Pretreatment of animals with tested plants extract (100, 200, and 400 mg/kg b. w.) caused significant alteration in total antioxidants, oxidants, and enzymes activities in paw tissue homogenate and the effect was more pronounced at higher concentration (400 mg/kg b. w.). Results showed that tested plants extract are rich source of diverse classes of phenolics and have therapeutic potential against oxidative stress and inflammation.
format	article
author	Hina Fatima Muhammad Shahid Amer Jamil Muhammad Naveed
author_facet	Hina Fatima Muhammad Shahid Amer Jamil Muhammad Naveed
author_sort	Hina Fatima
title	Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
title_short	Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
title_full	Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
title_fullStr	Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
title_full_unstemmed	Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats
title_sort	therapeutic potential of selected medicinal plants against carrageenan induced inflammation in rats
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/64b74198800341b88a2522e748a2f083
work_keys_str_mv	AT hinafatima therapeuticpotentialofselectedmedicinalplantsagainstcarrageenaninducedinflammationinrats AT muhammadshahid therapeuticpotentialofselectedmedicinalplantsagainstcarrageenaninducedinflammationinrats AT amerjamil therapeuticpotentialofselectedmedicinalplantsagainstcarrageenaninducedinflammationinrats AT muhammadnaveed therapeuticpotentialofselectedmedicinalplantsagainstcarrageenaninducedinflammationinrats
_version_	1718403987472908288

Therapeutic Potential of Selected Medicinal Plants Against Carrageenan Induced Inflammation in Rats

Ejemplares similares