TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS

The content of autoantibodies to TNF in the sera of patients with rheumatoid arthritis (RA) in conjunction with the definition of soluble receptors and TNF was investigated. A significant increase in the content of TNF and I and II types soluble receptors to TNF in sera of RA patients in the acute s...

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Autores principales:	E. A. Golikova, J. A. Lopatnikova, N. S. Shkaruba, A. E. Sizikov, S. V. Sennikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	autoantibodies tumor necrosis factor rheumatoid arthritis Science Q
Acceso en línea:	https://doaj.org/article/64ba37c0ef6f4753aaab7d07512959d4
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spelling	oai:doaj.org-article:64ba37c0ef6f4753aaab7d07512959d42021-11-23T06:14:19ZTNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS2541-94202587-9596https://doaj.org/article/64ba37c0ef6f4753aaab7d07512959d42012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/887https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The content of autoantibodies to TNF in the sera of patients with rheumatoid arthritis (RA) in conjunction with the definition of soluble receptors and TNF was investigated. A significant increase in the content of TNF and I and II types soluble receptors to TNF in sera of RA patients in the acute stage and of responding to therapy RA patients compared with relatively healthy donors was demonstrated. In determining autoantibodies subclasses a significant increase in the relative content of subclasses IgG2, IgG3 and IgG4 autoantibodies in sera of RA patients in the acute stage compared with relatively healthy donors, as well as a significant increase in the relative content of subclasses IgG2 and IgG4 autoantibodies in RA patients in the acute stage compared with RA patients, responding to therapy were shown. Thus we have shown the presence of antibodies, soluble receptors to TNF and cytokine in the serum of relatively healthy donors and RA patients, herewith taking into account significant changes in the relative content of the subclasses of autoantibodies and in the content of TNF and soluble receptors we can talk about the functional role of the autoantibodies and soluble receptors to TNF in the pathology.E. A. GolikovaJ. A. LopatnikovaN. S. ShkarubaA. E. SizikovS. V. SennikovScientific Сentre for Family Health and Human Reproduction Problemsarticleautoantibodiestumor necrosis factorrheumatoid arthritisScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 67-71 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies tumor necrosis factor rheumatoid arthritis Science Q
spellingShingle	autoantibodies tumor necrosis factor rheumatoid arthritis Science Q E. A. Golikova J. A. Lopatnikova N. S. Shkaruba A. E. Sizikov S. V. Sennikov TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
description	The content of autoantibodies to TNF in the sera of patients with rheumatoid arthritis (RA) in conjunction with the definition of soluble receptors and TNF was investigated. A significant increase in the content of TNF and I and II types soluble receptors to TNF in sera of RA patients in the acute stage and of responding to therapy RA patients compared with relatively healthy donors was demonstrated. In determining autoantibodies subclasses a significant increase in the relative content of subclasses IgG2, IgG3 and IgG4 autoantibodies in sera of RA patients in the acute stage compared with relatively healthy donors, as well as a significant increase in the relative content of subclasses IgG2 and IgG4 autoantibodies in RA patients in the acute stage compared with RA patients, responding to therapy were shown. Thus we have shown the presence of antibodies, soluble receptors to TNF and cytokine in the serum of relatively healthy donors and RA patients, herewith taking into account significant changes in the relative content of the subclasses of autoantibodies and in the content of TNF and soluble receptors we can talk about the functional role of the autoantibodies and soluble receptors to TNF in the pathology.
format	article
author	E. A. Golikova J. A. Lopatnikova N. S. Shkaruba A. E. Sizikov S. V. Sennikov
author_facet	E. A. Golikova J. A. Lopatnikova N. S. Shkaruba A. E. Sizikov S. V. Sennikov
author_sort	E. A. Golikova
title	TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
title_short	TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
title_full	TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
title_fullStr	TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
title_full_unstemmed	TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS
title_sort	tnf, soluble receptors and autoantibodies to tnf of patients with rheumatoid arthritis and healthy donors
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/64ba37c0ef6f4753aaab7d07512959d4
work_keys_str_mv	AT eagolikova tnfsolublereceptorsandautoantibodiestotnfofpatientswithrheumatoidarthritisandhealthydonors AT jalopatnikova tnfsolublereceptorsandautoantibodiestotnfofpatientswithrheumatoidarthritisandhealthydonors AT nsshkaruba tnfsolublereceptorsandautoantibodiestotnfofpatientswithrheumatoidarthritisandhealthydonors AT aesizikov tnfsolublereceptorsandautoantibodiestotnfofpatientswithrheumatoidarthritisandhealthydonors AT svsennikov tnfsolublereceptorsandautoantibodiestotnfofpatientswithrheumatoidarthritisandhealthydonors
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TNF, SOLUBLE RECEPTORS AND AUTOANTIBODIES TO TNF OF PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY DONORS

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