Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells

Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.

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Autores principales: Shuang Peng, Binglin Bie, Yangzesheng Sun, Min Liu, Hengjiang Cong, Wentao Zhou, Yucong Xia, Heng Tang, Hexiang Deng, Xiang Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f8
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spelling oai:doaj.org-article:64ba95d8d87f433fb0c97c49bbd8a5f82021-12-02T14:39:28ZMetal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells10.1038/s41467-018-03650-w2041-1723https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03650-whttps://doaj.org/toc/2041-1723Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.Shuang PengBinglin BieYangzesheng SunMin LiuHengjiang CongWentao ZhouYucong XiaHeng TangHexiang DengXiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuang Peng
Binglin Bie
Yangzesheng Sun
Min Liu
Hengjiang Cong
Wentao Zhou
Yucong Xia
Heng Tang
Hexiang Deng
Xiang Zhou
Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
description Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.
format article
author Shuang Peng
Binglin Bie
Yangzesheng Sun
Min Liu
Hengjiang Cong
Wentao Zhou
Yucong Xia
Heng Tang
Hexiang Deng
Xiang Zhou
author_facet Shuang Peng
Binglin Bie
Yangzesheng Sun
Min Liu
Hengjiang Cong
Wentao Zhou
Yucong Xia
Heng Tang
Hexiang Deng
Xiang Zhou
author_sort Shuang Peng
title Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_short Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_full Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_fullStr Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_full_unstemmed Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_sort metal-organic frameworks for precise inclusion of single-stranded dna and transfection in immune cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f8
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