Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells

Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.

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Main Authors:	Shuang Peng, Binglin Bie, Yangzesheng Sun, Min Liu, Hengjiang Cong, Wentao Zhou, Yucong Xia, Heng Tang, Hexiang Deng, Xiang Zhou
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f8
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spelling	oai:doaj.org-article:64ba95d8d87f433fb0c97c49bbd8a5f82021-12-02T14:39:28ZMetal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells10.1038/s41467-018-03650-w2041-1723https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f82018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03650-whttps://doaj.org/toc/2041-1723Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.Shuang PengBinglin BieYangzesheng SunMin LiuHengjiang CongWentao ZhouYucong XiaHeng TangHexiang DengXiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuang Peng Binglin Bie Yangzesheng Sun Min Liu Hengjiang Cong Wentao Zhou Yucong Xia Heng Tang Hexiang Deng Xiang Zhou Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
description	Non-viral vectors are important for transfection but can be limited in the uptake, protection and release of ssDNA. Here, the authors report on the design of metal-organic-framework vectors with precisely controlled pore geometry and demonstrate the vector in the transfection of immune cells.
format	article
author	Shuang Peng Binglin Bie Yangzesheng Sun Min Liu Hengjiang Cong Wentao Zhou Yucong Xia Heng Tang Hexiang Deng Xiang Zhou
author_facet	Shuang Peng Binglin Bie Yangzesheng Sun Min Liu Hengjiang Cong Wentao Zhou Yucong Xia Heng Tang Hexiang Deng Xiang Zhou
author_sort	Shuang Peng
title	Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_short	Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_full	Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_fullStr	Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_full_unstemmed	Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
title_sort	metal-organic frameworks for precise inclusion of single-stranded dna and transfection in immune cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/64ba95d8d87f433fb0c97c49bbd8a5f8
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Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells

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