Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?

Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the <i>MTHFR</i> gene. The hum...

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Autores principales:	Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	folic acid homocysteine inflammatory bowel disease microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/64ca08f0a16b45ce8188ee2ac4888cd6
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spelling	oai:doaj.org-article:64ca08f0a16b45ce8188ee2ac4888cd62021-11-25T18:36:16ZDoes Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?10.3390/nu131140362072-6643https://doaj.org/article/64ca08f0a16b45ce8188ee2ac4888cd62021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4036https://doaj.org/toc/2072-6643Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the <i>MTHFR</i> gene. The human body is not able to synthesize folic acid; thus, it must be supplemented with diet. The most common consequence of folic acid deficiency is anemia; however, some studies have also demonstrated the correlation between low bone mineral density, hyperhomocysteinemia, and folic acid deficiency. Patients with inflammatory bowel disease (IBD) frequently suffer from malabsorption and avoid certain products, such as fresh fruits and vegetables, which constitute the main sources of vitamin B9. Additionally, the use of sulfasalazine by patients may result in folic acid deficiency. Therefore, IBD patients present a higher risk of folic acid deficiency and require particular supervision with regard to anemia and osteoporosis prevention, which are common consequences of IBD.Alicja Ewa RatajczakAleksandra Szymczak-TomczakAnna Maria RychterAgnieszka ZawadaAgnieszka DobrowolskaIwona Krela-KaźmierczakMDPI AGarticlefolic acidhomocysteineinflammatory bowel diseasemicrobiotaNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4036, p 4036 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	folic acid homocysteine inflammatory bowel disease microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	folic acid homocysteine inflammatory bowel disease microbiota Nutrition. Foods and food supply TX341-641 Alicja Ewa Ratajczak Aleksandra Szymczak-Tomczak Anna Maria Rychter Agnieszka Zawada Agnieszka Dobrowolska Iwona Krela-Kaźmierczak Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
description	Folic acid, referred to as vitamin B9, is a water-soluble substance, which participates in the synthesis of nucleic acids, amino acids, and proteins. Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the <i>MTHFR</i> gene. The human body is not able to synthesize folic acid; thus, it must be supplemented with diet. The most common consequence of folic acid deficiency is anemia; however, some studies have also demonstrated the correlation between low bone mineral density, hyperhomocysteinemia, and folic acid deficiency. Patients with inflammatory bowel disease (IBD) frequently suffer from malabsorption and avoid certain products, such as fresh fruits and vegetables, which constitute the main sources of vitamin B9. Additionally, the use of sulfasalazine by patients may result in folic acid deficiency. Therefore, IBD patients present a higher risk of folic acid deficiency and require particular supervision with regard to anemia and osteoporosis prevention, which are common consequences of IBD.
format	article
author	Alicja Ewa Ratajczak Aleksandra Szymczak-Tomczak Anna Maria Rychter Agnieszka Zawada Agnieszka Dobrowolska Iwona Krela-Kaźmierczak
author_facet	Alicja Ewa Ratajczak Aleksandra Szymczak-Tomczak Anna Maria Rychter Agnieszka Zawada Agnieszka Dobrowolska Iwona Krela-Kaźmierczak
author_sort	Alicja Ewa Ratajczak
title	Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
title_short	Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
title_full	Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
title_fullStr	Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
title_full_unstemmed	Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?
title_sort	does folic acid protect patients with inflammatory bowel disease from complications?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/64ca08f0a16b45ce8188ee2ac4888cd6
work_keys_str_mv	AT alicjaewaratajczak doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications AT aleksandraszymczaktomczak doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications AT annamariarychter doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications AT agnieszkazawada doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications AT agnieszkadobrowolska doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications AT iwonakrelakazmierczak doesfolicacidprotectpatientswithinflammatoryboweldiseasefromcomplications
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Does Folic Acid Protect Patients with Inflammatory Bowel Disease from Complications?

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