Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa

Abstract Some clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on na...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lauriana Alves Santana, Suellen Karoline Moreira Bezerra, Beatriz Mangueira Saraiva-Romanholo, Wellington Pereira Yamaguti, Iolanda de Fátima Lopes Calvo Tibério, Tabata Maruyama dos Santos, Renato Fraga Righetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64ca604907ac4b1483cdbff2686df915
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64ca604907ac4b1483cdbff2686df915
record_format	dspace
spelling	oai:doaj.org-article:64ca604907ac4b1483cdbff2686df9152021-12-02T18:30:45ZCold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa10.1038/s41598-021-93837-x2045-2322https://doaj.org/article/64ca604907ac4b1483cdbff2686df9152021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93837-xhttps://doaj.org/toc/2045-2322Abstract Some clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on nasal Inflammation, oxidative stress, mucociliary clearance, and nasal symptoms. This is a randomized controlled cross-sectional study in which healthy subjects were randomly allocated into four groups: (1) CA + DRY (n = 8): individuals receiving dry compressed air; (2) OX + DRY (n = 8): individuals receiving dry oxygen therapy; (3) CA + HUMID (n = 7): individuals receiving cold bubbled humidified compressed air; (4) OX + HUMID (n = 8): individuals receiving cold bubbled humidified oxygen therapy. All groups received 3 L per minute (LPM) of the oxygen or compressed air for 1 h and were evaluated: total and differential cells in the nasal lavage fluid (NLF), exhaled nitric oxide (eNO), 8-iso-PGF2α levels, saccharin transit test, nasal symptoms, and humidity of nasal cannula and mucosa. Cold bubble humidification is not able to reduced nasal inflammation, eNO, oxidative stress, mucociliary clearance, and nasal mucosa moisture. However, subjects report improvement of nasal dryness symptoms (P < 0.05). In the conclusion, cold bubble humidification of low flow oxygen therapy via a nasal cannula did not produce any effect on the nasal mucosa and did not attenuate the oxidative stress caused by oxygen. However, it was able to improve nasal symptoms arising from the use of oxygen therapy.Lauriana Alves SantanaSuellen Karoline Moreira BezerraBeatriz Mangueira Saraiva-RomanholoWellington Pereira YamagutiIolanda de Fátima Lopes Calvo TibérioTabata Maruyama dos SantosRenato Fraga RighettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lauriana Alves Santana Suellen Karoline Moreira Bezerra Beatriz Mangueira Saraiva-Romanholo Wellington Pereira Yamaguti Iolanda de Fátima Lopes Calvo Tibério Tabata Maruyama dos Santos Renato Fraga Righetti Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
description	Abstract Some clinical situations require the use of oxygen therapy for a few hours without hypoxemia. However, there are no literature reports on the effects of acute oxygen therapy on the nasal mucosa. This study aimed to evaluate the acute effects of cold bubble humidification or dry oxygen on nasal Inflammation, oxidative stress, mucociliary clearance, and nasal symptoms. This is a randomized controlled cross-sectional study in which healthy subjects were randomly allocated into four groups: (1) CA + DRY (n = 8): individuals receiving dry compressed air; (2) OX + DRY (n = 8): individuals receiving dry oxygen therapy; (3) CA + HUMID (n = 7): individuals receiving cold bubbled humidified compressed air; (4) OX + HUMID (n = 8): individuals receiving cold bubbled humidified oxygen therapy. All groups received 3 L per minute (LPM) of the oxygen or compressed air for 1 h and were evaluated: total and differential cells in the nasal lavage fluid (NLF), exhaled nitric oxide (eNO), 8-iso-PGF2α levels, saccharin transit test, nasal symptoms, and humidity of nasal cannula and mucosa. Cold bubble humidification is not able to reduced nasal inflammation, eNO, oxidative stress, mucociliary clearance, and nasal mucosa moisture. However, subjects report improvement of nasal dryness symptoms (P < 0.05). In the conclusion, cold bubble humidification of low flow oxygen therapy via a nasal cannula did not produce any effect on the nasal mucosa and did not attenuate the oxidative stress caused by oxygen. However, it was able to improve nasal symptoms arising from the use of oxygen therapy.
format	article
author	Lauriana Alves Santana Suellen Karoline Moreira Bezerra Beatriz Mangueira Saraiva-Romanholo Wellington Pereira Yamaguti Iolanda de Fátima Lopes Calvo Tibério Tabata Maruyama dos Santos Renato Fraga Righetti
author_facet	Lauriana Alves Santana Suellen Karoline Moreira Bezerra Beatriz Mangueira Saraiva-Romanholo Wellington Pereira Yamaguti Iolanda de Fátima Lopes Calvo Tibério Tabata Maruyama dos Santos Renato Fraga Righetti
author_sort	Lauriana Alves Santana
title	Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
title_short	Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
title_full	Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
title_fullStr	Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
title_full_unstemmed	Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
title_sort	cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64ca604907ac4b1483cdbff2686df915
work_keys_str_mv	AT laurianaalvessantana coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT suellenkarolinemoreirabezerra coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT beatrizmangueirasaraivaromanholo coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT wellingtonpereirayamaguti coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT iolandadefatimalopescalvotiberio coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT tabatamaruyamadossantos coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa AT renatofragarighetti coldbubblehumidificationoflowflowoxygendoesnotpreventacutechangesininflammationandoxidativestressatnasalmucosa
_version_	1718377980663693312

Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa

Ejemplares similares