Advances in nanocarriers as drug delivery systems in Chagas disease

Christian Quijia Quezada,1,2 Clênia S Azevedo,1 Sébastien Charneau,3 Jaime M Santana,1 Marlus Chorilli,2 Marcella B Carneiro,4 Izabela Marques Dourado Bastos11Pathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biology, University of Brasilia, Bras&i...

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Autores principales:	Quijia Quezada C, Azevedo CS, Charneau S, Santana JM, Chorilli M, Carneiro MB, Bastos IMD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Delivery systems nanobiosensors nanodiagnostics nanoparticle systems nanovaccine. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/64cbfb128db34ec180f3a074e35afcba
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spelling	oai:doaj.org-article:64cbfb128db34ec180f3a074e35afcba2021-12-02T04:45:50ZAdvances in nanocarriers as drug delivery systems in Chagas disease1178-2013https://doaj.org/article/64cbfb128db34ec180f3a074e35afcba2019-08-01T00:00:00Zhttps://www.dovepress.com/advances-in-nanocarriers-as-drug-delivery-systems-in-chagas-disease-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Christian Quijia Quezada,1,2 Clênia S Azevedo,1 Sébastien Charneau,3 Jaime M Santana,1 Marlus Chorilli,2 Marcella B Carneiro,4 Izabela Marques Dourado Bastos11Pathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, Brazil; 2Department of Drugs and Medicines, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil; 3Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, Brazil; 4Electron Microscopy Laboratory, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, BrazilAbstract: Chagas disease is one of the most important public health problems in Latin America due to its high mortality and morbidity levels. There is no effective treatment for this disease since drugs are usually toxic with low bioavailability. Serious efforts to achieve disease control and eventual eradication have been unsuccessful to date, emphasizing the need for rapid diagnosis, drug development, and a reliable vaccine. Novel systems for drug and vaccine administration based on nanocarriers represent a promising avenue for Chagas disease treatment. Nanoparticulate systems can reduce toxicity, and increase the efficacy and bioavailability of active compounds by prolonging release, and therefore improve the therapeutic index. Moreover, nanoparticles are able to interact with the host’s immune system, modulating the immune response to favour the elimination of pathogenic microorganisms. In addition, new advances in diagnostic assays, such as nanobiosensors, are beneficial in that they enable precise identification of the pathogen. In this review, we provide an overview of the strategies and nanocarrier-based delivery systems for antichagasic agents, such as liposomes, micelles, nanoemulsions, polymeric and non-polymeric nanoparticles. We address recent progress, with a particular focus on the advances of nanovaccines and nanodiagnostics, exploring new perspectives on Chagas disease treatment.Keywords: delivery systems, nanobiosensors, nanodiagnostics, nanoparticle systems, nanovaccineQuijia Quezada CAzevedo CSCharneau SSantana JMChorilli MCarneiro MBBastos IMDDove Medical PressarticleDelivery systemsnanobiosensorsnanodiagnosticsnanoparticle systemsnanovaccine.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 6407-6424 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Delivery systems nanobiosensors nanodiagnostics nanoparticle systems nanovaccine. Medicine (General) R5-920
spellingShingle	Delivery systems nanobiosensors nanodiagnostics nanoparticle systems nanovaccine. Medicine (General) R5-920 Quijia Quezada C Azevedo CS Charneau S Santana JM Chorilli M Carneiro MB Bastos IMD Advances in nanocarriers as drug delivery systems in Chagas disease
description	Christian Quijia Quezada,1,2 Clênia S Azevedo,1 Sébastien Charneau,3 Jaime M Santana,1 Marlus Chorilli,2 Marcella B Carneiro,4 Izabela Marques Dourado Bastos11Pathogen-Host Interface Laboratory, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, Brazil; 2Department of Drugs and Medicines, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil; 3Laboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, Brazil; 4Electron Microscopy Laboratory, Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, BrazilAbstract: Chagas disease is one of the most important public health problems in Latin America due to its high mortality and morbidity levels. There is no effective treatment for this disease since drugs are usually toxic with low bioavailability. Serious efforts to achieve disease control and eventual eradication have been unsuccessful to date, emphasizing the need for rapid diagnosis, drug development, and a reliable vaccine. Novel systems for drug and vaccine administration based on nanocarriers represent a promising avenue for Chagas disease treatment. Nanoparticulate systems can reduce toxicity, and increase the efficacy and bioavailability of active compounds by prolonging release, and therefore improve the therapeutic index. Moreover, nanoparticles are able to interact with the host’s immune system, modulating the immune response to favour the elimination of pathogenic microorganisms. In addition, new advances in diagnostic assays, such as nanobiosensors, are beneficial in that they enable precise identification of the pathogen. In this review, we provide an overview of the strategies and nanocarrier-based delivery systems for antichagasic agents, such as liposomes, micelles, nanoemulsions, polymeric and non-polymeric nanoparticles. We address recent progress, with a particular focus on the advances of nanovaccines and nanodiagnostics, exploring new perspectives on Chagas disease treatment.Keywords: delivery systems, nanobiosensors, nanodiagnostics, nanoparticle systems, nanovaccine
format	article
author	Quijia Quezada C Azevedo CS Charneau S Santana JM Chorilli M Carneiro MB Bastos IMD
author_facet	Quijia Quezada C Azevedo CS Charneau S Santana JM Chorilli M Carneiro MB Bastos IMD
author_sort	Quijia Quezada C
title	Advances in nanocarriers as drug delivery systems in Chagas disease
title_short	Advances in nanocarriers as drug delivery systems in Chagas disease
title_full	Advances in nanocarriers as drug delivery systems in Chagas disease
title_fullStr	Advances in nanocarriers as drug delivery systems in Chagas disease
title_full_unstemmed	Advances in nanocarriers as drug delivery systems in Chagas disease
title_sort	advances in nanocarriers as drug delivery systems in chagas disease
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/64cbfb128db34ec180f3a074e35afcba
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Advances in nanocarriers as drug delivery systems in Chagas disease

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