Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Alterations in glycosylation in tumours facilitate tumour progression. Here, the authors show that pancreatic ductal adenocarcinomas present increased sialylation, which stimulates the polarisation of monocytes via Siglec receptors, resulting in the generation of immune suppressive tumour associated...

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Autores principales:	Ernesto Rodriguez, Kelly Boelaars, Kari Brown, R. J. Eveline Li, Laura Kruijssen, Sven C. M. Bruijns, Thomas van Ee, Sjoerd T. T. Schetters, Matheus H. W. Crommentuijn, Joost C. van der Horst, Nicole C. T. van Grieken, Sandra J. van Vliet, Geert Kazemier, Elisa Giovannetti, Juan J. Garcia-Vallejo, Yvette van Kooyk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64cd1d7410f74f27b60dd9aca97082ae
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spelling	oai:doaj.org-article:64cd1d7410f74f27b60dd9aca97082ae2021-12-02T13:34:44ZSialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-910.1038/s41467-021-21550-42041-1723https://doaj.org/article/64cd1d7410f74f27b60dd9aca97082ae2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21550-4https://doaj.org/toc/2041-1723Alterations in glycosylation in tumours facilitate tumour progression. Here, the authors show that pancreatic ductal adenocarcinomas present increased sialylation, which stimulates the polarisation of monocytes via Siglec receptors, resulting in the generation of immune suppressive tumour associated macrophages.Ernesto RodriguezKelly BoelaarsKari BrownR. J. Eveline LiLaura KruijssenSven C. M. BruijnsThomas van EeSjoerd T. T. SchettersMatheus H. W. CrommentuijnJoost C. van der HorstNicole C. T. van GriekenSandra J. van VlietGeert KazemierElisa GiovannettiJuan J. Garcia-VallejoYvette van KooykNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ernesto Rodriguez Kelly Boelaars Kari Brown R. J. Eveline Li Laura Kruijssen Sven C. M. Bruijns Thomas van Ee Sjoerd T. T. Schetters Matheus H. W. Crommentuijn Joost C. van der Horst Nicole C. T. van Grieken Sandra J. van Vliet Geert Kazemier Elisa Giovannetti Juan J. Garcia-Vallejo Yvette van Kooyk Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
description	Alterations in glycosylation in tumours facilitate tumour progression. Here, the authors show that pancreatic ductal adenocarcinomas present increased sialylation, which stimulates the polarisation of monocytes via Siglec receptors, resulting in the generation of immune suppressive tumour associated macrophages.
format	article
author	Ernesto Rodriguez Kelly Boelaars Kari Brown R. J. Eveline Li Laura Kruijssen Sven C. M. Bruijns Thomas van Ee Sjoerd T. T. Schetters Matheus H. W. Crommentuijn Joost C. van der Horst Nicole C. T. van Grieken Sandra J. van Vliet Geert Kazemier Elisa Giovannetti Juan J. Garcia-Vallejo Yvette van Kooyk
author_facet	Ernesto Rodriguez Kelly Boelaars Kari Brown R. J. Eveline Li Laura Kruijssen Sven C. M. Bruijns Thomas van Ee Sjoerd T. T. Schetters Matheus H. W. Crommentuijn Joost C. van der Horst Nicole C. T. van Grieken Sandra J. van Vliet Geert Kazemier Elisa Giovannetti Juan J. Garcia-Vallejo Yvette van Kooyk
author_sort	Ernesto Rodriguez
title	Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
title_short	Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
title_full	Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
title_fullStr	Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
title_full_unstemmed	Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
title_sort	sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the siglec receptors siglec-7 and siglec-9
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64cd1d7410f74f27b60dd9aca97082ae
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Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

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