Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates efficient centriolar targeting of STIL, PLK4 activ...

Full description

Saved in:
Bibliographic Details
Main Authors: Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/64d5bf6e3d9f4b17ae080b2ad6edfff9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/64d5bf6e3d9f4b17ae080b2ad6edfff9

Similar Items