Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates efficient centriolar targeting of STIL, PLK4 activ...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/64d5bf6e3d9f4b17ae080b2ad6edfff9
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Documents similaires