Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma

Abstract Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of...

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Autores principales:	Qian Song, Jun-zhou Wu, Sheng Wang, Wen-hu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64d775fb03c348b08865217b7be36cab
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spelling	oai:doaj.org-article:64d775fb03c348b08865217b7be36cab2021-12-02T16:08:17ZElevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma10.1038/s41598-019-51675-y2045-2322https://doaj.org/article/64d775fb03c348b08865217b7be36cab2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51675-yhttps://doaj.org/toc/2045-2322Abstract Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with ESCC undergoing curative surgery were enrolled. The relationship between PDW and clinical features in ESCC was analyzed using chi-square tests. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value. Overall survival (OS) and disease-free survival (DFS) stratified by PDW were evaluated by Kaplan–Meier method and log-rank test. Univariate and multivariate Cox regression were used to evaluate the prognostic effect of PDW. Of the 495 patients, elevated PDW was observed in 241(48.7%) of the patients, respectively. An elevated PDW was correlated with depth of tumor (T stage, P = 0.031), nerve infiltration (P = 0.016), hospital time after operation (P = 0.020), platelet (P < 0.001), red cell distribution width (P < 0.001), and aspartate transaminase (P = 0.001). Moreover, elevated PDW (PDW ≥ 13.4 fL) predicted a worse OS and DFS in patients with ESCC (both P < 0.001). Multivariate analyses revealed that PDW was independently associated with OS (hazard ratios 1.194; 95% confidence interval 1.120–1.273; P < 0.001) and DFS (hazard ratios 2.562; 95% confidence interval 1.733–3.786; P < 0.001). Our findings indicated that elevated PDW could serve as an independent worse survival in ESCC.Qian SongJun-zhou WuSheng WangWen-hu ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qian Song Jun-zhou Wu Sheng Wang Wen-hu Chen Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
description	Abstract Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with ESCC undergoing curative surgery were enrolled. The relationship between PDW and clinical features in ESCC was analyzed using chi-square tests. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value. Overall survival (OS) and disease-free survival (DFS) stratified by PDW were evaluated by Kaplan–Meier method and log-rank test. Univariate and multivariate Cox regression were used to evaluate the prognostic effect of PDW. Of the 495 patients, elevated PDW was observed in 241(48.7%) of the patients, respectively. An elevated PDW was correlated with depth of tumor (T stage, P = 0.031), nerve infiltration (P = 0.016), hospital time after operation (P = 0.020), platelet (P < 0.001), red cell distribution width (P < 0.001), and aspartate transaminase (P = 0.001). Moreover, elevated PDW (PDW ≥ 13.4 fL) predicted a worse OS and DFS in patients with ESCC (both P < 0.001). Multivariate analyses revealed that PDW was independently associated with OS (hazard ratios 1.194; 95% confidence interval 1.120–1.273; P < 0.001) and DFS (hazard ratios 2.562; 95% confidence interval 1.733–3.786; P < 0.001). Our findings indicated that elevated PDW could serve as an independent worse survival in ESCC.
format	article
author	Qian Song Jun-zhou Wu Sheng Wang Wen-hu Chen
author_facet	Qian Song Jun-zhou Wu Sheng Wang Wen-hu Chen
author_sort	Qian Song
title	Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
title_short	Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
title_full	Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
title_fullStr	Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
title_full_unstemmed	Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
title_sort	elevated preoperative platelet distribution width predicts poor prognosis in esophageal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/64d775fb03c348b08865217b7be36cab
work_keys_str_mv	AT qiansong elevatedpreoperativeplateletdistributionwidthpredictspoorprognosisinesophagealsquamouscellcarcinoma AT junzhouwu elevatedpreoperativeplateletdistributionwidthpredictspoorprognosisinesophagealsquamouscellcarcinoma AT shengwang elevatedpreoperativeplateletdistributionwidthpredictspoorprognosisinesophagealsquamouscellcarcinoma AT wenhuchen elevatedpreoperativeplateletdistributionwidthpredictspoorprognosisinesophagealsquamouscellcarcinoma
_version_	1718384532707606528

Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma

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