MRI findings in 77 children with non-syndromic autistic disorder.

MRI findings in 77 children with non-syndromic autistic disorder.

<h4>Background</h4>The clinical relevance of MR scanning in children with autism is still an open question and must be considered in light of the evolution of this technology. MRI was judged to be of insufficient value to be included in the standard clinical evaluation of autism accordin...

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Autores principales: Nathalie Boddaert, Mônica Zilbovicius, Anne Philipe, Laurence Robel, Marie Bourgeois, Catherine Barthélemy, David Seidenwurm, Isabelle Meresse, Laurence Laurier, Isabelle Desguerre, Nadia Bahi-Buisson, Francis Brunelle, Arnold Munnich, Yves Samson, Marie-Christine Mouren, Nadia Chabane
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Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/64d890ce07d14296823bfe45afdd7f8f
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spelling oai:doaj.org-article:64d890ce07d14296823bfe45afdd7f8f2021-11-25T06:17:24ZMRI findings in 77 children with non-syndromic autistic disorder.1932-620310.1371/journal.pone.0004415https://doaj.org/article/64d890ce07d14296823bfe45afdd7f8f2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19204795/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The clinical relevance of MR scanning in children with autism is still an open question and must be considered in light of the evolution of this technology. MRI was judged to be of insufficient value to be included in the standard clinical evaluation of autism according to the guidelines of the American Academy of Neurology and Child Neurology Society in 2000. However, this statement was based on results obtained from small samples of patients and, more importantly, included mostly insufficient MRI sequences. Our main objective was to evaluate the prevalence of brain abnormalities in a large group of children with a non-syndromic autistic disorder (AD) using T1, T2 and FLAIR MRI sequences.<h4>Methodology</h4>MRI inspection of 77 children and adolescents with non-syndromic AD (mean age 7.4+/-3.6) was performed. All met the DSM-IV and ADI -R criteria for autism. Based on recommended clinical and biological screenings, we excluded patients with infectious, metabolic or genetic diseases, seizures or any other neurological symptoms. Identical MRI inspections of 77 children (mean age 7.0+/-4.2) without AD, developmental or neurological disorders were also performed. All MRIs were acquired with a 1.5-T Signa GE (3-D T1-FSPGR, T2, FLAIR coronal and axial sequences). Two neuroradiologists independently inspected cortical and sub-cortical regions. MRIs were reported to be normal, abnormal or uninterpretable.<h4>Principal findings</h4>MRIs were judged as uninterpretable in 10% (8/77) of the cases. In 48% of the children (33/69 patients), abnormalities were reported. Three predominant abnormalities were observed, including white matter signal abnormalities (19/69), major dilated Virchow-Robin spaces (12/69) and temporal lobe abnormalities (20/69). In all, 52% of the MRIs were interpreted as normal (36/69 patients).<h4>Conclusions</h4>An unexpectedly high rate of MRI abnormalities was found in the first large series of clinical MRI investigations in non-syndromic autism. These results could contribute to further etiopathogenetic research into autism.Nathalie BoddaertMônica ZilboviciusAnne PhilipeLaurence RobelMarie BourgeoisCatherine BarthélemyDavid SeidenwurmIsabelle MeresseLaurence LaurierIsabelle DesguerreNadia Bahi-BuissonFrancis BrunelleArnold MunnichYves SamsonMarie-Christine MourenNadia ChabanePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 2, p e4415 (2009)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Nathalie Boddaert
Mônica Zilbovicius
Anne Philipe
Laurence Robel
Marie Bourgeois
Catherine Barthélemy
David Seidenwurm
Isabelle Meresse
Laurence Laurier
Isabelle Desguerre
Nadia Bahi-Buisson
Francis Brunelle
Arnold Munnich
Yves Samson
Marie-Christine Mouren
Nadia Chabane
MRI findings in 77 children with non-syndromic autistic disorder.
description <h4>Background</h4>The clinical relevance of MR scanning in children with autism is still an open question and must be considered in light of the evolution of this technology. MRI was judged to be of insufficient value to be included in the standard clinical evaluation of autism according to the guidelines of the American Academy of Neurology and Child Neurology Society in 2000. However, this statement was based on results obtained from small samples of patients and, more importantly, included mostly insufficient MRI sequences. Our main objective was to evaluate the prevalence of brain abnormalities in a large group of children with a non-syndromic autistic disorder (AD) using T1, T2 and FLAIR MRI sequences.<h4>Methodology</h4>MRI inspection of 77 children and adolescents with non-syndromic AD (mean age 7.4+/-3.6) was performed. All met the DSM-IV and ADI -R criteria for autism. Based on recommended clinical and biological screenings, we excluded patients with infectious, metabolic or genetic diseases, seizures or any other neurological symptoms. Identical MRI inspections of 77 children (mean age 7.0+/-4.2) without AD, developmental or neurological disorders were also performed. All MRIs were acquired with a 1.5-T Signa GE (3-D T1-FSPGR, T2, FLAIR coronal and axial sequences). Two neuroradiologists independently inspected cortical and sub-cortical regions. MRIs were reported to be normal, abnormal or uninterpretable.<h4>Principal findings</h4>MRIs were judged as uninterpretable in 10% (8/77) of the cases. In 48% of the children (33/69 patients), abnormalities were reported. Three predominant abnormalities were observed, including white matter signal abnormalities (19/69), major dilated Virchow-Robin spaces (12/69) and temporal lobe abnormalities (20/69). In all, 52% of the MRIs were interpreted as normal (36/69 patients).<h4>Conclusions</h4>An unexpectedly high rate of MRI abnormalities was found in the first large series of clinical MRI investigations in non-syndromic autism. These results could contribute to further etiopathogenetic research into autism.
format article
author Nathalie Boddaert
Mônica Zilbovicius
Anne Philipe
Laurence Robel
Marie Bourgeois
Catherine Barthélemy
David Seidenwurm
Isabelle Meresse
Laurence Laurier
Isabelle Desguerre
Nadia Bahi-Buisson
Francis Brunelle
Arnold Munnich
Yves Samson
Marie-Christine Mouren
Nadia Chabane
author_facet Nathalie Boddaert
Mônica Zilbovicius
Anne Philipe
Laurence Robel
Marie Bourgeois
Catherine Barthélemy
David Seidenwurm
Isabelle Meresse
Laurence Laurier
Isabelle Desguerre
Nadia Bahi-Buisson
Francis Brunelle
Arnold Munnich
Yves Samson
Marie-Christine Mouren
Nadia Chabane
author_sort Nathalie Boddaert
title MRI findings in 77 children with non-syndromic autistic disorder.
title_short MRI findings in 77 children with non-syndromic autistic disorder.
title_full MRI findings in 77 children with non-syndromic autistic disorder.
title_fullStr MRI findings in 77 children with non-syndromic autistic disorder.
title_full_unstemmed MRI findings in 77 children with non-syndromic autistic disorder.
title_sort mri findings in 77 children with non-syndromic autistic disorder.
publisher Public Library of Science (PLoS)
publishDate 2009
url https://doaj.org/article/64d890ce07d14296823bfe45afdd7f8f
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