EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)

BACKGROUND AND OBJECTIVE: Different studies have reported different results for expression of cell-cycle regulator genes, P53 and P27kip1, and proliferation marker Ki-67 in gastric cancer and their correlation with clinicohistopathologic parameters and outcome. The aim of this study was to study the...

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Autores principales:	E Shafigh, Y Abdolazimi, SH Shafaei, M Haji Ahmadi
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2007
Materias:	gastric cancer p53 p27 ki-67 immunohistochemistry Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/64d908cb54af4768af5d437d0485d938
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spelling	oai:doaj.org-article:64d908cb54af4768af5d437d0485d9382021-11-10T09:10:17ZEXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)1561-41072251-7170https://doaj.org/article/64d908cb54af4768af5d437d0485d9382007-10-01T00:00:00Zhttp://jbums.org/article-1-2516-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Different studies have reported different results for expression of cell-cycle regulator genes, P53 and P27kip1, and proliferation marker Ki-67 in gastric cancer and their correlation with clinicohistopathologic parameters and outcome. The aim of this study was to study the expression rate of P53,P27kip1, Ki-67 and their correlation with histopathological features and subsequently biological behavior in gastric cancer. METHODS: In this experimental (laboratory) study, 58 paraffin-embedded blocks from patients who underwent gastrectomy were stained by hematoxylin-eosin and then immunohistochemistry against P53, P27kip1 and Ki-67. The statistical associations between clinicopathological parameters and immunohistochemical results were tested by Chi- Square and Fishers- exact test using SPSS. FINDINGS: Male: female=2.86:1 median age= 60, antral location (27 cases), ulcerating macroscopic appearance (29 cases), intestinal (40 cases) and infiltrative type (48 cases) were the most frequent findings. Histological grade G1 (differentiated, 29 cases) and T3 + T4 stages (49 cases) were the most frequent. Number of cases with lymph node metastasis, vascular and neural invasion was 41, 49 and 47, respectively. Expression rate of P53, P27Kip1 and Ki-67 were 56.9%, 56.9% and 75.9%, respectively. There was only a significant correlation between expression of P53 and Ki-67 (p= 0.028, r=0.323).CONCLUSION: According to the results, studying the expression of P53, P27kip1 and Ki-67 markers alone do not have diagnostic value in predicting the biological behavior of gastric cancer.E Shafigh,Y AbdolazimiSH ShafaeiM Haji AhmadiBabol University of Medical Sciencesarticlegastric cancerp53p27ki-67immunohistochemistryMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 9, Iss 4, Pp 7-14 (2007)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	gastric cancer p53 p27 ki-67 immunohistochemistry Medicine R Medicine (General) R5-920
spellingShingle	gastric cancer p53 p27 ki-67 immunohistochemistry Medicine R Medicine (General) R5-920 E Shafigh, Y Abdolazimi SH Shafaei M Haji Ahmadi EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
description	BACKGROUND AND OBJECTIVE: Different studies have reported different results for expression of cell-cycle regulator genes, P53 and P27kip1, and proliferation marker Ki-67 in gastric cancer and their correlation with clinicohistopathologic parameters and outcome. The aim of this study was to study the expression rate of P53,P27kip1, Ki-67 and their correlation with histopathological features and subsequently biological behavior in gastric cancer. METHODS: In this experimental (laboratory) study, 58 paraffin-embedded blocks from patients who underwent gastrectomy were stained by hematoxylin-eosin and then immunohistochemistry against P53, P27kip1 and Ki-67. The statistical associations between clinicopathological parameters and immunohistochemical results were tested by Chi- Square and Fishers- exact test using SPSS. FINDINGS: Male: female=2.86:1 median age= 60, antral location (27 cases), ulcerating macroscopic appearance (29 cases), intestinal (40 cases) and infiltrative type (48 cases) were the most frequent findings. Histological grade G1 (differentiated, 29 cases) and T3 + T4 stages (49 cases) were the most frequent. Number of cases with lymph node metastasis, vascular and neural invasion was 41, 49 and 47, respectively. Expression rate of P53, P27Kip1 and Ki-67 were 56.9%, 56.9% and 75.9%, respectively. There was only a significant correlation between expression of P53 and Ki-67 (p= 0.028, r=0.323).CONCLUSION: According to the results, studying the expression of P53, P27kip1 and Ki-67 markers alone do not have diagnostic value in predicting the biological behavior of gastric cancer.
format	article
author	E Shafigh, Y Abdolazimi SH Shafaei M Haji Ahmadi
author_facet	E Shafigh, Y Abdolazimi SH Shafaei M Haji Ahmadi
author_sort	E Shafigh,
title	EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
title_short	EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
title_full	EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
title_fullStr	EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
title_full_unstemmed	EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)
title_sort	expression of p53, p27kip1and ki-67 in gastric cancer and their correlation with clinicohistopathologic parameters in shahid beheshti hospital (babol 2000-2006)
publisher	Babol University of Medical Sciences
publishDate	2007
url	https://doaj.org/article/64d908cb54af4768af5d437d0485d938
work_keys_str_mv	AT eshafigh expressionofp53p27kip1andki67ingastriccancerandtheircorrelationwithclinicohistopathologicparametersinshahidbeheshtihospitalbabol20002006 AT yabdolazimi expressionofp53p27kip1andki67ingastriccancerandtheircorrelationwithclinicohistopathologicparametersinshahidbeheshtihospitalbabol20002006 AT shshafaei expressionofp53p27kip1andki67ingastriccancerandtheircorrelationwithclinicohistopathologicparametersinshahidbeheshtihospitalbabol20002006 AT mhajiahmadi expressionofp53p27kip1andki67ingastriccancerandtheircorrelationwithclinicohistopathologicparametersinshahidbeheshtihospitalbabol20002006
_version_	1718440198168117248

EXPRESSION OF P53, P27kip1AND Ki-67 IN GASTRIC CANCER AND THEIR CORRELATION WITH CLINICOHISTOPATHOLOGIC PARAMETERS IN SHAHID BEHESHTI HOSPITAL (BABOL 2000-2006)

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