Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.

<h4>Background</h4>Previous studies have found that healthcare-associated bacteremia (HAB) by Aeromonas species is associated with mortality. However, there is limited data on this outcome in patients with hematologic malignancies. This study aimed to identify the clinical features of pa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bryan Valcarcel, Gabriel De-la-Cruz-Ku, Luis Malpica, Daniel Enriquez-Vera
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64d942270c2749afa5f1ba5f04768dcc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64d942270c2749afa5f1ba5f04768dcc
record_format	dspace
spelling	oai:doaj.org-article:64d942270c2749afa5f1ba5f04768dcc2021-12-02T20:18:22ZClinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.1932-620310.1371/journal.pone.0255910https://doaj.org/article/64d942270c2749afa5f1ba5f04768dcc2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255910https://doaj.org/toc/1932-6203<h4>Background</h4>Previous studies have found that healthcare-associated bacteremia (HAB) by Aeromonas species is associated with mortality. However, there is limited data on this outcome in patients with hematologic malignancies. This study aimed to identify the clinical features of patients with malignant hematologic diseases diagnosed with Aeromonas sobria bacteremia and to evaluate whether the type of bacteremia, community-acquired bacteremia (CAB) or HAB, is associated with mortality.<h4>Methods</h4>We retrospectively reviewed the clinical records of pediatric and adult patients between January 2000 and December 2017. Clinical characteristics were compared between CAB and HAB. Additionally, we stratified based on age group. Survival outcomes were assessed with Kaplan-Meier curves and a multivariate Cox regression analysis.<h4>Results</h4>A total of 37 patients (median age 24 years) were identified; 23 (62%) had HAB and 14 (38%) had CAB. Overall, the most common presenting symptom was abdominal pain (41%). Acute lymphoblastic leukemia (n = 12/15, 80%) and acute myeloid leukemia (n = 8/22, 36%) were the primary hematologic malignancies in pediatric and adult patients, respectively. CAB patients had worse overall survival (OS) rates at 30 days in all (43% versus HAB 91%, p = 0.006) and adult patients (30% versus HAB 92%, p = 0.002). Cox regression analysis found that quick Sequential Organ Failure Assessment and CAB were statistically significant factors associated with mortality. Low antimicrobial-resistant was noted, except for ciprofloxacin (n = 5/37, 14%).<h4>Conclusion</h4>Our study found a worse OS among patients with hematologic malignancies and CAB by Aeromonas sobria. Our results suggest that patients with CAB present with a worse disease severity. These findings should aid clinicians to determine the survival prognosis in this population.Bryan ValcarcelGabriel De-la-Cruz-KuLuis MalpicaDaniel Enriquez-VeraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255910 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryan Valcarcel Gabriel De-la-Cruz-Ku Luis Malpica Daniel Enriquez-Vera Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
description	<h4>Background</h4>Previous studies have found that healthcare-associated bacteremia (HAB) by Aeromonas species is associated with mortality. However, there is limited data on this outcome in patients with hematologic malignancies. This study aimed to identify the clinical features of patients with malignant hematologic diseases diagnosed with Aeromonas sobria bacteremia and to evaluate whether the type of bacteremia, community-acquired bacteremia (CAB) or HAB, is associated with mortality.<h4>Methods</h4>We retrospectively reviewed the clinical records of pediatric and adult patients between January 2000 and December 2017. Clinical characteristics were compared between CAB and HAB. Additionally, we stratified based on age group. Survival outcomes were assessed with Kaplan-Meier curves and a multivariate Cox regression analysis.<h4>Results</h4>A total of 37 patients (median age 24 years) were identified; 23 (62%) had HAB and 14 (38%) had CAB. Overall, the most common presenting symptom was abdominal pain (41%). Acute lymphoblastic leukemia (n = 12/15, 80%) and acute myeloid leukemia (n = 8/22, 36%) were the primary hematologic malignancies in pediatric and adult patients, respectively. CAB patients had worse overall survival (OS) rates at 30 days in all (43% versus HAB 91%, p = 0.006) and adult patients (30% versus HAB 92%, p = 0.002). Cox regression analysis found that quick Sequential Organ Failure Assessment and CAB were statistically significant factors associated with mortality. Low antimicrobial-resistant was noted, except for ciprofloxacin (n = 5/37, 14%).<h4>Conclusion</h4>Our study found a worse OS among patients with hematologic malignancies and CAB by Aeromonas sobria. Our results suggest that patients with CAB present with a worse disease severity. These findings should aid clinicians to determine the survival prognosis in this population.
format	article
author	Bryan Valcarcel Gabriel De-la-Cruz-Ku Luis Malpica Daniel Enriquez-Vera
author_facet	Bryan Valcarcel Gabriel De-la-Cruz-Ku Luis Malpica Daniel Enriquez-Vera
author_sort	Bryan Valcarcel
title	Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
title_short	Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
title_full	Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
title_fullStr	Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
title_full_unstemmed	Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.
title_sort	clinical features and outcome of aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: a single-center retrospective study in peru.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/64d942270c2749afa5f1ba5f04768dcc
work_keys_str_mv	AT bryanvalcarcel clinicalfeaturesandoutcomeofaeromonassobriabacteremiainpediatricandadultpatientswithhematologicmalignanciesasinglecenterretrospectivestudyinperu AT gabrieldelacruzku clinicalfeaturesandoutcomeofaeromonassobriabacteremiainpediatricandadultpatientswithhematologicmalignanciesasinglecenterretrospectivestudyinperu AT luismalpica clinicalfeaturesandoutcomeofaeromonassobriabacteremiainpediatricandadultpatientswithhematologicmalignanciesasinglecenterretrospectivestudyinperu AT danielenriquezvera clinicalfeaturesandoutcomeofaeromonassobriabacteremiainpediatricandadultpatientswithhematologicmalignanciesasinglecenterretrospectivestudyinperu
_version_	1718374287425929216

Clinical features and outcome of Aeromonas sobria bacteremia in pediatric and adult patients with hematologic malignancies: A single-center retrospective study in Peru.

Ejemplares similares