INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Universidad de Antioquia
2009
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/64df11181edc41b4aa519ca95db4d5b6 |
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| Sumario: | Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural
component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as
a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic
leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian
marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y
Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most
of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament
used against cancer which is used as a control for the bioassays. Results demonstrate that some of the
analyzed extracts have more inhibition than the control metotrexate®.
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