INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME

Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like...

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Autores principales:	Diego A. ZABALA, Bibiana ECAVARRÍA, Alejandro MARTÍNEZ
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Dihydrofolate reductase metotrexate® marine sponges. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/64df11181edc41b4aa519ca95db4d5b6
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spelling	oai:doaj.org-article:64df11181edc41b4aa519ca95db4d5b62021-11-19T04:17:05ZINHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME0121-40042145-2660https://doaj.org/article/64df11181edc41b4aa519ca95db4d5b62009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/802https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament used against cancer which is used as a control for the bioassays. Results demonstrate that some of the analyzed extracts have more inhibition than the control metotrexate®. Diego A. ZABALABibiana ECAVARRÍAAlejandro MARTÍNEZUniversidad de AntioquiaarticleDihydrofolate reductasemetotrexate®marine sponges.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dihydrofolate reductase metotrexate® marine sponges. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Dihydrofolate reductase metotrexate® marine sponges. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
description	Dihydrofolate reductase is an enzyme involved in the production of pyrimidinic base timidin, a structural component of DNA, therefore whatever substance that inhibit this enzyme inhibit the DNA synthesis as a consequence and it can be potentially useful as a treatment of several types of cancer like lymphoblastic leukemias. In this work we determinate the inhibition grade that the ethanol extracts from Colombian marine sponges: Svenzea zeai, Amphimedon compressa, Ircinia campana, Aplysina archeri, Xestospongia proxima y Xestospongia muta, over the human purified enzyme dihydrofolate reductase. The results shown that most of marine sponge extracts inhibite the enzyme. Results are compared with methotrexate® a medicament used against cancer which is used as a control for the bioassays. Results demonstrate that some of the analyzed extracts have more inhibition than the control metotrexate®.
format	article
author	Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ
author_facet	Diego A. ZABALA Bibiana ECAVARRÍA Alejandro MARTÍNEZ
author_sort	Diego A. ZABALA
title	INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
title_short	INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
title_full	INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
title_fullStr	INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
title_full_unstemmed	INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME
title_sort	inhibitory activity of some marine sponge extracts from urabá gulf on dihydrofolate reductase enzyme
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/64df11181edc41b4aa519ca95db4d5b6
work_keys_str_mv	AT diegoazabala inhibitoryactivityofsomemarinespongeextractsfromurabagulfondihydrofolatereductaseenzyme AT bibianaecavarria inhibitoryactivityofsomemarinespongeextractsfromurabagulfondihydrofolatereductaseenzyme AT alejandromartinez inhibitoryactivityofsomemarinespongeextractsfromurabagulfondihydrofolatereductaseenzyme
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INHIBITORY ACTIVITY OF SOME MARINE SPONGE EXTRACTS FROM URABÁ GULF ON DIHYDROFOLATE REDUCTASE ENZYME

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