FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS

Studies of functional activity of neutrophilic granulocytes from patients with chronic rhinosinusitis was performed using luminol- or lucigenin-dependent chemiluminescence. We have revealed increased production of reactive oxygen species (ROS) both under basal conditions, and in zymozan-induced chem...

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Autores principales:	O. A. Kolenchukova, A. A. Savchenko, S. V. Smirnova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutrophilic granulocytes luminol lucigenin reactive oxygen species rhinosinusitis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/64e3515f0c69404191ba5901067a0e64
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spelling	oai:doaj.org-article:64e3515f0c69404191ba5901067a0e642021-11-18T08:03:41ZFEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS1563-06252313-741X10.15789/1563-0625-2010-4-5-437-440https://doaj.org/article/64e3515f0c69404191ba5901067a0e642014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/404https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XStudies of functional activity of neutrophilic granulocytes from patients with chronic rhinosinusitis was performed using luminol- or lucigenin-dependent chemiluminescence. We have revealed increased production of reactive oxygen species (ROS) both under basal conditions, and in zymozan-induced chemiluminescent reaction, employing luminol as an activator, and determining total functional activity of neutrophils. Meanwhile, in lucigenin-induced chemiluminescence associated with production of superoxide anion radicals, a delayed ROS production was revealed, both in spontaneous and zymozan-induced response. One may suggest that, when studying these pathological events in neutrophils, ROS production in the cells proceeds mostly by myeloperoxidase pathway.O. A. KolenchukovaA. A. SavchenkoS. V. SmirnovaSPb RAACIarticleneutrophilic granulocytesluminollucigeninreactive oxygen speciesrhinosinusitisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 437-440 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutrophilic granulocytes luminol lucigenin reactive oxygen species rhinosinusitis Immunologic diseases. Allergy RC581-607
spellingShingle	neutrophilic granulocytes luminol lucigenin reactive oxygen species rhinosinusitis Immunologic diseases. Allergy RC581-607 O. A. Kolenchukova A. A. Savchenko S. V. Smirnova FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
description	Studies of functional activity of neutrophilic granulocytes from patients with chronic rhinosinusitis was performed using luminol- or lucigenin-dependent chemiluminescence. We have revealed increased production of reactive oxygen species (ROS) both under basal conditions, and in zymozan-induced chemiluminescent reaction, employing luminol as an activator, and determining total functional activity of neutrophils. Meanwhile, in lucigenin-induced chemiluminescence associated with production of superoxide anion radicals, a delayed ROS production was revealed, both in spontaneous and zymozan-induced response. One may suggest that, when studying these pathological events in neutrophils, ROS production in the cells proceeds mostly by myeloperoxidase pathway.
format	article
author	O. A. Kolenchukova A. A. Savchenko S. V. Smirnova
author_facet	O. A. Kolenchukova A. A. Savchenko S. V. Smirnova
author_sort	O. A. Kolenchukova
title	FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
title_short	FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
title_full	FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
title_fullStr	FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
title_full_unstemmed	FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS
title_sort	features of luminol- and lucigenin-induced chemiluminescence of neutrophilic granulocytes in patients with chronic rhinosinusitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/64e3515f0c69404191ba5901067a0e64
work_keys_str_mv	AT oakolenchukova featuresofluminolandlucigenininducedchemiluminescenceofneutrophilicgranulocytesinpatientswithchronicrhinosinusitis AT aasavchenko featuresofluminolandlucigenininducedchemiluminescenceofneutrophilicgranulocytesinpatientswithchronicrhinosinusitis AT svsmirnova featuresofluminolandlucigenininducedchemiluminescenceofneutrophilicgranulocytesinpatientswithchronicrhinosinusitis
_version_	1718422480386785280

FEATURES OF LUMINOL- AND LUCIGENIN-INDUCED CHEMILUMINESCENCE OF NEUTROPHILIC GRANULOCYTES IN PATIENTS WITH CHRONIC RHINOSINUSITIS

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