Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loa...

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Autores principales:	Murali K. Akula, Mohamed X. Ibrahim, Emil G. Ivarsson, Omar M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, Xiufeng Xu, Mikael Brisslert, Cord Brakebusch, Donghai Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64e45db836524099a563e469b049824a
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spelling	oai:doaj.org-article:64e45db836524099a563e469b049824a2021-12-02T14:39:19ZProtein prenylation restrains innate immunity by inhibiting Rac1 effector interactions10.1038/s41467-019-11606-x2041-1723https://doaj.org/article/64e45db836524099a563e469b049824a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11606-xhttps://doaj.org/toc/2041-1723Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loading of RAC1 and enhanced proinflammatory cytokine production.Murali K. AkulaMohamed X. IbrahimEmil G. IvarssonOmar M. KhanIsraiel T. KumarMalin ErlandssonChristin KarlssonXiufeng XuMikael BrisslertCord BrakebuschDonghai WangMaria BokarewaVolkan I. SayinMartin O. BergoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Murali K. Akula Mohamed X. Ibrahim Emil G. Ivarsson Omar M. Khan Israiel T. Kumar Malin Erlandsson Christin Karlsson Xiufeng Xu Mikael Brisslert Cord Brakebusch Donghai Wang Maria Bokarewa Volkan I. Sayin Martin O. Bergo Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
description	Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loading of RAC1 and enhanced proinflammatory cytokine production.
format	article
author	Murali K. Akula Mohamed X. Ibrahim Emil G. Ivarsson Omar M. Khan Israiel T. Kumar Malin Erlandsson Christin Karlsson Xiufeng Xu Mikael Brisslert Cord Brakebusch Donghai Wang Maria Bokarewa Volkan I. Sayin Martin O. Bergo
author_facet	Murali K. Akula Mohamed X. Ibrahim Emil G. Ivarsson Omar M. Khan Israiel T. Kumar Malin Erlandsson Christin Karlsson Xiufeng Xu Mikael Brisslert Cord Brakebusch Donghai Wang Maria Bokarewa Volkan I. Sayin Martin O. Bergo
author_sort	Murali K. Akula
title	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
title_short	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
title_full	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
title_fullStr	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
title_full_unstemmed	Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
title_sort	protein prenylation restrains innate immunity by inhibiting rac1 effector interactions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/64e45db836524099a563e469b049824a
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

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