Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with the adaptor protein IQGAP1, leading to GTP-loa...

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Autores principales: Murali K. Akula, Mohamed X. Ibrahim, Emil G. Ivarsson, Omar M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, Xiufeng Xu, Mikael Brisslert, Cord Brakebusch, Donghai Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/64e45db836524099a563e469b049824a
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