Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses

Following activation, GABAA receptors (GABAARs) undergo desensitization, the impact of which on inhibitory neurotransmission remains unknown. Here the authors describe an enduring form of long-term potentiation at inhibitory synapses that elevates synaptic current amplitude for 24 h following desens...

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Autores principales:	Martin Field, Valentina Dorovykh, Philip Thomas, Trevor G. Smart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64e617fac6b54c9eab042c395c7c5614
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spelling	oai:doaj.org-article:64e617fac6b54c9eab042c395c7c56142021-12-02T18:15:35ZPhysiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses10.1038/s41467-021-22420-92041-1723https://doaj.org/article/64e617fac6b54c9eab042c395c7c56142021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22420-9https://doaj.org/toc/2041-1723Following activation, GABAA receptors (GABAARs) undergo desensitization, the impact of which on inhibitory neurotransmission remains unknown. Here the authors describe an enduring form of long-term potentiation at inhibitory synapses that elevates synaptic current amplitude for 24 h following desensitization of GABAARs.Martin FieldValentina DorovykhPhilip ThomasTrevor G. SmartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Field Valentina Dorovykh Philip Thomas Trevor G. Smart Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
description	Following activation, GABAA receptors (GABAARs) undergo desensitization, the impact of which on inhibitory neurotransmission remains unknown. Here the authors describe an enduring form of long-term potentiation at inhibitory synapses that elevates synaptic current amplitude for 24 h following desensitization of GABAARs.
format	article
author	Martin Field Valentina Dorovykh Philip Thomas Trevor G. Smart
author_facet	Martin Field Valentina Dorovykh Philip Thomas Trevor G. Smart
author_sort	Martin Field
title	Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
title_short	Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
title_full	Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
title_fullStr	Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
title_full_unstemmed	Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
title_sort	physiological role for gabaa receptor desensitization in the induction of long-term potentiation at inhibitory synapses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64e617fac6b54c9eab042c395c7c5614
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Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses

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