Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens

Abstract Feather pecking (FP) is a stress-induced neuropsychological disorder of birds. Intestinal dysbiosis and inflammation are common traits of these disorders. FP is, therefore, proposed to be a behavioral consequence of dysregulated communication between the gut and the brain. Probiotic bacteri...

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Autores principales:	Claire Mindus, Nienke van Staaveren, Aadil Bharwani, Dietmar Fuchs, Johanna M. Gostner, Joergen B. Kjaer, Wolfgang Kunze, M. Firoz Mian, Anna K. Shoveller, Paul Forsythe, Alexandra Harlander-Matauschek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64e7e4e108c04b82a78701d4bbc7d05b
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spelling	oai:doaj.org-article:64e7e4e108c04b82a78701d4bbc7d05b2021-12-02T15:09:06ZIngestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens10.1038/s41598-021-96615-x2045-2322https://doaj.org/article/64e7e4e108c04b82a78701d4bbc7d05b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96615-xhttps://doaj.org/toc/2045-2322Abstract Feather pecking (FP) is a stress-induced neuropsychological disorder of birds. Intestinal dysbiosis and inflammation are common traits of these disorders. FP is, therefore, proposed to be a behavioral consequence of dysregulated communication between the gut and the brain. Probiotic bacteria are known to favorably modulate the gut microbiome and hence the neurochemical and immune components of the gut-brain axis. Consequently, probiotic supplementation represents a promising new therapeutic to mitigate widespread FP in domestic chickens. We monitored FP, gut microbiota composition, immune markers, and amino acids related to the production of neurochemicals in chickens supplemented with Lactobacillus rhamnosus or a placebo. Data demonstrate that, when stressed, the incidence of FP increased significantly; however, L. rhamnosus prevented this increase. L. rhamnosus supplementation showed a strong immunological effect by increasing the regulatory T cell population of the spleen and the cecal tonsils, in addition to limiting cecal microbiota dysbiosis. Despite minimal changes in aromatic amino acid levels, data suggest that catecholaminergic circuits may be an interesting target for further studies. Overall, our findings provide the first data supporting the use of a single-strain probiotic to reduce stress-induced FP in chickens and promise to improve domestic birds' welfare.Claire MindusNienke van StaaverenAadil BharwaniDietmar FuchsJohanna M. GostnerJoergen B. KjaerWolfgang KunzeM. Firoz MianAnna K. ShovellerPaul ForsytheAlexandra Harlander-MatauschekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire Mindus Nienke van Staaveren Aadil Bharwani Dietmar Fuchs Johanna M. Gostner Joergen B. Kjaer Wolfgang Kunze M. Firoz Mian Anna K. Shoveller Paul Forsythe Alexandra Harlander-Matauschek Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
description	Abstract Feather pecking (FP) is a stress-induced neuropsychological disorder of birds. Intestinal dysbiosis and inflammation are common traits of these disorders. FP is, therefore, proposed to be a behavioral consequence of dysregulated communication between the gut and the brain. Probiotic bacteria are known to favorably modulate the gut microbiome and hence the neurochemical and immune components of the gut-brain axis. Consequently, probiotic supplementation represents a promising new therapeutic to mitigate widespread FP in domestic chickens. We monitored FP, gut microbiota composition, immune markers, and amino acids related to the production of neurochemicals in chickens supplemented with Lactobacillus rhamnosus or a placebo. Data demonstrate that, when stressed, the incidence of FP increased significantly; however, L. rhamnosus prevented this increase. L. rhamnosus supplementation showed a strong immunological effect by increasing the regulatory T cell population of the spleen and the cecal tonsils, in addition to limiting cecal microbiota dysbiosis. Despite minimal changes in aromatic amino acid levels, data suggest that catecholaminergic circuits may be an interesting target for further studies. Overall, our findings provide the first data supporting the use of a single-strain probiotic to reduce stress-induced FP in chickens and promise to improve domestic birds' welfare.
format	article
author	Claire Mindus Nienke van Staaveren Aadil Bharwani Dietmar Fuchs Johanna M. Gostner Joergen B. Kjaer Wolfgang Kunze M. Firoz Mian Anna K. Shoveller Paul Forsythe Alexandra Harlander-Matauschek
author_facet	Claire Mindus Nienke van Staaveren Aadil Bharwani Dietmar Fuchs Johanna M. Gostner Joergen B. Kjaer Wolfgang Kunze M. Firoz Mian Anna K. Shoveller Paul Forsythe Alexandra Harlander-Matauschek
author_sort	Claire Mindus
title	Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
title_short	Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
title_full	Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
title_fullStr	Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
title_full_unstemmed	Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
title_sort	ingestion of lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64e7e4e108c04b82a78701d4bbc7d05b
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Ingestion of Lactobacillus rhamnosus modulates chronic stress-induced feather pecking in chickens

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