Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models

Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Gao, Shasha Cui, Zhiqiang Huang, Hailong Cui, Tahani Awad Alahmadi, Velu Manikandan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/64e931cef692420d829e95bcdebe4b97
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64e931cef692420d829e95bcdebe4b97
record_format	dspace
spelling	oai:doaj.org-article:64e931cef692420d829e95bcdebe4b972021-11-20T04:56:45ZAntinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models1319-562X10.1016/j.sjbs.2021.08.006https://doaj.org/article/64e931cef692420d829e95bcdebe4b972021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006793https://doaj.org/toc/1319-562XBackground: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.Li GaoShasha CuiZhiqiang HuangHailong CuiTahani Awad AlahmadiVelu ManikandanElsevierarticleNociceptionButeinInflammationTail immersionCapsaicinBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7090-7097 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) QH301-705.5
spellingShingle	Nociception Butein Inflammation Tail immersion Capsaicin Biology (General) QH301-705.5 Li Gao Shasha Cui Zhiqiang Huang Hailong Cui Tahani Awad Alahmadi Velu Manikandan Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
description	Background: Around 30% world population affected by acute and chronic pain due to inflammation and accidental injuries. Pain is a uncomfortable sensation and it reduce the patients’ life quality. Objective: The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models. Methodology: The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods. the mice were supplemented with 10, 15, and 20 mg/kg of butein and respective standard drugs like morphine, diclofenac sodium, and dexamethasone. The anti-inflammatory effects of butein was studied using carrageenan-provoked inflammation in mice. Results: The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. The carrageenan-triggered paw edema and inflammatory cell infiltrations were appreciably suppressed by the butein treatment. The TNF-α, IL-1β, and IL-6 levels in the carrageenan-induced mice were effectively depleted by the butein. Conclusion: Altogether, the present findings evidenced the potent antinociceptive and anti-inflammatory properties of the butein in different nociceptive mice models.
format	article
author	Li Gao Shasha Cui Zhiqiang Huang Hailong Cui Tahani Awad Alahmadi Velu Manikandan
author_facet	Li Gao Shasha Cui Zhiqiang Huang Hailong Cui Tahani Awad Alahmadi Velu Manikandan
author_sort	Li Gao
title	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
title_short	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
title_full	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
title_fullStr	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
title_full_unstemmed	Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
title_sort	antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/64e931cef692420d829e95bcdebe4b97
work_keys_str_mv	AT ligao antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels AT shashacui antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels AT zhiqianghuang antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels AT hailongcui antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels AT tahaniawadalahmadi antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels AT velumanikandan antinociceptiveandantiinflammatoryactivitiesofbuteinindifferentnociceptiveandinflammatorymicemodels
_version_	1718419718102056960

Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models

Ejemplares similares