A comparison among three maximal mathematical models of the glucose-insulin system.

The most well-known and widely used mathematical representations of the physiology of a diabetic individual are the Sorensen and Hovorka models as well as the UVAPadova Simulator. While the Hovorka model and the UVAPadova Simulator only describe the glucose metabolism of a subject with type 1 diabet...

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Autores principales:	Marcello Pompa, Simona Panunzi, Alessandro Borri, Andrea De Gaetano
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64e96bb8d6f84a91805caaf4c2a35b98
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spelling	oai:doaj.org-article:64e96bb8d6f84a91805caaf4c2a35b982021-12-02T20:14:08ZA comparison among three maximal mathematical models of the glucose-insulin system.1932-620310.1371/journal.pone.0257789https://doaj.org/article/64e96bb8d6f84a91805caaf4c2a35b982021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257789https://doaj.org/toc/1932-6203The most well-known and widely used mathematical representations of the physiology of a diabetic individual are the Sorensen and Hovorka models as well as the UVAPadova Simulator. While the Hovorka model and the UVAPadova Simulator only describe the glucose metabolism of a subject with type 1 diabetes, the Sorensen model was formulated to simulate the behaviour of both normal and diabetic individuals. The UVAPadova model is the most known model, accepted by the FDA, with a high level of complexity. The Hovorka model is the simplest of the three models, well documented and used primarily for the development of control algorithms. The Sorensen model is the most complete, even though some modifications were required both to the model equations (adding useful compartments for modelling subcutaneous insulin delivery) and to the parameter values. In the present work several simulated experiments, such as IVGTTs and OGTTs, were used as tools to compare the three formulations in order to establish to what extent increasing complexity translates into richer and more correct physiological behaviour. All the equations and parameters used for carrying out the simulations are provided.Marcello PompaSimona PanunziAlessandro BorriAndrea De GaetanoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257789 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcello Pompa Simona Panunzi Alessandro Borri Andrea De Gaetano A comparison among three maximal mathematical models of the glucose-insulin system.
description	The most well-known and widely used mathematical representations of the physiology of a diabetic individual are the Sorensen and Hovorka models as well as the UVAPadova Simulator. While the Hovorka model and the UVAPadova Simulator only describe the glucose metabolism of a subject with type 1 diabetes, the Sorensen model was formulated to simulate the behaviour of both normal and diabetic individuals. The UVAPadova model is the most known model, accepted by the FDA, with a high level of complexity. The Hovorka model is the simplest of the three models, well documented and used primarily for the development of control algorithms. The Sorensen model is the most complete, even though some modifications were required both to the model equations (adding useful compartments for modelling subcutaneous insulin delivery) and to the parameter values. In the present work several simulated experiments, such as IVGTTs and OGTTs, were used as tools to compare the three formulations in order to establish to what extent increasing complexity translates into richer and more correct physiological behaviour. All the equations and parameters used for carrying out the simulations are provided.
format	article
author	Marcello Pompa Simona Panunzi Alessandro Borri Andrea De Gaetano
author_facet	Marcello Pompa Simona Panunzi Alessandro Borri Andrea De Gaetano
author_sort	Marcello Pompa
title	A comparison among three maximal mathematical models of the glucose-insulin system.
title_short	A comparison among three maximal mathematical models of the glucose-insulin system.
title_full	A comparison among three maximal mathematical models of the glucose-insulin system.
title_fullStr	A comparison among three maximal mathematical models of the glucose-insulin system.
title_full_unstemmed	A comparison among three maximal mathematical models of the glucose-insulin system.
title_sort	comparison among three maximal mathematical models of the glucose-insulin system.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/64e96bb8d6f84a91805caaf4c2a35b98
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A comparison among three maximal mathematical models of the glucose-insulin system.

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