Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.

<h4>Background</h4>Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the prote...

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Autores principales:	Beata Ujvari, Thomas Madsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64ebd8cf7ad24370aa88feed58780b5a
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spelling	oai:doaj.org-article:64ebd8cf7ad24370aa88feed58780b5a2021-11-25T06:28:42ZShort telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.1932-620310.1371/journal.pone.0007493https://doaj.org/article/64ebd8cf7ad24370aa88feed58780b5a2009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19834611/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL. In the present study we explore whether age- and sex-specific telomere dynamics affect life span in a long-lived snake, the water python (Liasis fuscus).<h4>Methodology/principal findings</h4>Erythrocyte TL was measured using the Telo TAGGG TL Assay Kit (Roche). In contrast to other vertebrates, TL of hatchling pythons was significantly shorter than that of older snakes. However, during their first year of life hatchling TL increased substantially. While TL of older snakes decreased with age, we did not observe any correlation between TL and age in cross-sectional sampling. In older snakes, female TL was longer than that of males. When using recapture as a proxy for survival, our results do not support that longer telomeres resulted in an increased water python survival/longevity.<h4>Conclusions/significance</h4>In fish high telomerase activity has been observed in somatic cells exhibiting high proliferation rates. Hatchling pythons show similar high somatic cell proliferation rates. Thus, the increase in TL of this group may have been caused by increased telomerase activity. In older humans female TL is longer than that of males. This has been suggested to be caused by high estrogen levels that stimulate increased telomerase activity. Thus, high estrogen levels may also have caused the longer telomeres in female pythons. The lack of correlation between TL and age among old snakes and the fact that longer telomeres did not appear to affect python survival do not support that erythrocyte telomere dynamics has a major impact on water python longevity.Beata UjvariThomas MadsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 10, p e7493 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beata Ujvari Thomas Madsen Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
description	<h4>Background</h4>Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL. In the present study we explore whether age- and sex-specific telomere dynamics affect life span in a long-lived snake, the water python (Liasis fuscus).<h4>Methodology/principal findings</h4>Erythrocyte TL was measured using the Telo TAGGG TL Assay Kit (Roche). In contrast to other vertebrates, TL of hatchling pythons was significantly shorter than that of older snakes. However, during their first year of life hatchling TL increased substantially. While TL of older snakes decreased with age, we did not observe any correlation between TL and age in cross-sectional sampling. In older snakes, female TL was longer than that of males. When using recapture as a proxy for survival, our results do not support that longer telomeres resulted in an increased water python survival/longevity.<h4>Conclusions/significance</h4>In fish high telomerase activity has been observed in somatic cells exhibiting high proliferation rates. Hatchling pythons show similar high somatic cell proliferation rates. Thus, the increase in TL of this group may have been caused by increased telomerase activity. In older humans female TL is longer than that of males. This has been suggested to be caused by high estrogen levels that stimulate increased telomerase activity. Thus, high estrogen levels may also have caused the longer telomeres in female pythons. The lack of correlation between TL and age among old snakes and the fact that longer telomeres did not appear to affect python survival do not support that erythrocyte telomere dynamics has a major impact on water python longevity.
format	article
author	Beata Ujvari Thomas Madsen
author_facet	Beata Ujvari Thomas Madsen
author_sort	Beata Ujvari
title	Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
title_short	Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
title_full	Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
title_fullStr	Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
title_full_unstemmed	Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
title_sort	short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/64ebd8cf7ad24370aa88feed58780b5a
work_keys_str_mv	AT beataujvari shorttelomeresinhatchlingsnakeserythrocytetelomeredynamicsandlongevityintropicalpythons AT thomasmadsen shorttelomeresinhatchlingsnakeserythrocytetelomeredynamicsandlongevityintropicalpythons
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Short telomeres in hatchling snakes: erythrocyte telomere dynamics and longevity in tropical pythons.

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