Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

ABSTRACT Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is...

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Autores principales:	Fikri Avci, Francesco Berti, Peter Dull, John Hennessey, Viliam Pavliak, A. Krishna Prasad, Willie Vann, Michael Wacker, Olivier Marcq
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	T-cell immunity capsular polysaccharide carrier protein clinical trials glycoconjugates immunity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/64ee4e5fc4dc4467b54c8d4b93621122
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id	oai:doaj.org-article:64ee4e5fc4dc4467b54c8d4b93621122
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spelling	oai:doaj.org-article:64ee4e5fc4dc4467b54c8d4b936211222021-11-15T15:27:33ZGlycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development10.1128/mSphere.00520-192379-5042https://doaj.org/article/64ee4e5fc4dc4467b54c8d4b936211222019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00520-19https://doaj.org/toc/2379-5042ABSTRACT Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.Fikri AvciFrancesco BertiPeter DullJohn HennesseyViliam PavliakA. Krishna PrasadWillie VannMichael WackerOlivier MarcqAmerican Society for MicrobiologyarticleT-cell immunitycapsular polysaccharidecarrier proteinclinical trialsglycoconjugatesimmunityMicrobiologyQR1-502ENmSphere, Vol 4, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	T-cell immunity capsular polysaccharide carrier protein clinical trials glycoconjugates immunity Microbiology QR1-502
spellingShingle	T-cell immunity capsular polysaccharide carrier protein clinical trials glycoconjugates immunity Microbiology QR1-502 Fikri Avci Francesco Berti Peter Dull John Hennessey Viliam Pavliak A. Krishna Prasad Willie Vann Michael Wacker Olivier Marcq Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
description	ABSTRACT Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.
format	article
author	Fikri Avci Francesco Berti Peter Dull John Hennessey Viliam Pavliak A. Krishna Prasad Willie Vann Michael Wacker Olivier Marcq
author_facet	Fikri Avci Francesco Berti Peter Dull John Hennessey Viliam Pavliak A. Krishna Prasad Willie Vann Michael Wacker Olivier Marcq
author_sort	Fikri Avci
title	Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_short	Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_full	Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_fullStr	Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_full_unstemmed	Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
title_sort	glycoconjugates: what it would take to master these well-known yet little-understood immunogens for vaccine development
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/64ee4e5fc4dc4467b54c8d4b93621122
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Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

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