Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish

The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.

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Autores principales: Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti, Yinxiong Li, Duanqing Pei, Xiaodong Shu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/64eea95ed93b4eecac80df588701028f
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spelling oai:doaj.org-article:64eea95ed93b4eecac80df588701028f2021-12-02T15:34:42ZDeficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish10.1038/s41467-018-05105-82041-1723https://doaj.org/article/64eea95ed93b4eecac80df588701028f2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05105-8https://doaj.org/toc/2041-1723The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.Shaoyang ZhaoJianhong XiaXiuhua WuLeilei ZhangPengtao WangHaiyun WangHeying LiXiaoshan WangYan ChenJean AgnettiYinxiong LiDuanqing PeiXiaodong ShuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shaoyang Zhao
Jianhong Xia
Xiuhua Wu
Leilei Zhang
Pengtao Wang
Haiyun Wang
Heying Li
Xiaoshan Wang
Yan Chen
Jean Agnetti
Yinxiong Li
Duanqing Pei
Xiaodong Shu
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
description The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.
format article
author Shaoyang Zhao
Jianhong Xia
Xiuhua Wu
Leilei Zhang
Pengtao Wang
Haiyun Wang
Heying Li
Xiaoshan Wang
Yan Chen
Jean Agnetti
Yinxiong Li
Duanqing Pei
Xiaodong Shu
author_facet Shaoyang Zhao
Jianhong Xia
Xiuhua Wu
Leilei Zhang
Pengtao Wang
Haiyun Wang
Heying Li
Xiaoshan Wang
Yan Chen
Jean Agnetti
Yinxiong Li
Duanqing Pei
Xiaodong Shu
author_sort Shaoyang Zhao
title Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
title_short Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
title_full Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
title_fullStr Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
title_full_unstemmed Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
title_sort deficiency in class iii pi3-kinase confers postnatal lethality with ibd-like features in zebrafish
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/64eea95ed93b4eecac80df588701028f
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AT jianhongxia deficiencyinclassiiipi3kinaseconferspostnatallethalitywithibdlikefeaturesinzebrafish
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AT heyingli deficiencyinclassiiipi3kinaseconferspostnatallethalitywithibdlikefeaturesinzebrafish
AT xiaoshanwang deficiencyinclassiiipi3kinaseconferspostnatallethalitywithibdlikefeaturesinzebrafish
AT yanchen deficiencyinclassiiipi3kinaseconferspostnatallethalitywithibdlikefeaturesinzebrafish
AT jeanagnetti deficiencyinclassiiipi3kinaseconferspostnatallethalitywithibdlikefeaturesinzebrafish
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