The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography

Abstract During a first-in-humans clinical trial investigating electron paramagnetic resonance tumor oximetry, a patient injected with the particulate oxygen sensor Printex ink was found to have unexpected fluorodeoxyglucose (FDG) uptake in a dermal nodule via positron emission tomography (PET). Thi...

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Autores principales:	Philip E. Schaner, Ly-Binh-An Tran, Bassem I. Zaki, Harold M. Swartz, Eugene Demidenko, Benjamin B. Williams, Alan Siegel, Periannan Kuppusamy, Ann Barry Flood, Bernard Gallez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/64f07c0a11434748a2d9a0bd74b7764a
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spelling	oai:doaj.org-article:64f07c0a11434748a2d9a0bd74b7764a2021-12-02T13:33:44ZThe impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography10.1038/s41598-021-82754-82045-2322https://doaj.org/article/64f07c0a11434748a2d9a0bd74b7764a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82754-8https://doaj.org/toc/2045-2322Abstract During a first-in-humans clinical trial investigating electron paramagnetic resonance tumor oximetry, a patient injected with the particulate oxygen sensor Printex ink was found to have unexpected fluorodeoxyglucose (FDG) uptake in a dermal nodule via positron emission tomography (PET). This nodule co-localized with the Printex ink injection; biopsy of the area, due to concern for malignancy, revealed findings consistent with ink and an associated inflammatory reaction. Investigations were subsequently performed to assess the impact of oxygen sensors on FDG-PET/CT imaging. A retrospective analysis of three clinical tumor oximetry trials involving two oxygen sensors (charcoal particulates and LiNc-BuO microcrystals) in 22 patients was performed to evaluate FDG imaging characteristics. The impact of clinically used oxygen sensors (carbon black, charcoal particulates, LiNc-BuO microcrystals) on FDG-PET/CT imaging after implantation in rat muscle (n = 12) was investigated. The retrospective review revealed no other patients with FDG avidity associated with particulate sensors. The preclinical investigation found no injected oxygen sensor whose mean standard uptake values differed significantly from sham injections. The risk of a false-positive FDG-PET/CT scan due to oxygen sensors appears low. However, in the right clinical context the potential exists that an associated inflammatory reaction may confound interpretation.Philip E. SchanerLy-Binh-An TranBassem I. ZakiHarold M. SwartzEugene DemidenkoBenjamin B. WilliamsAlan SiegelPeriannan KuppusamyAnn Barry FloodBernard GallezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philip E. Schaner Ly-Binh-An Tran Bassem I. Zaki Harold M. Swartz Eugene Demidenko Benjamin B. Williams Alan Siegel Periannan Kuppusamy Ann Barry Flood Bernard Gallez The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
description	Abstract During a first-in-humans clinical trial investigating electron paramagnetic resonance tumor oximetry, a patient injected with the particulate oxygen sensor Printex ink was found to have unexpected fluorodeoxyglucose (FDG) uptake in a dermal nodule via positron emission tomography (PET). This nodule co-localized with the Printex ink injection; biopsy of the area, due to concern for malignancy, revealed findings consistent with ink and an associated inflammatory reaction. Investigations were subsequently performed to assess the impact of oxygen sensors on FDG-PET/CT imaging. A retrospective analysis of three clinical tumor oximetry trials involving two oxygen sensors (charcoal particulates and LiNc-BuO microcrystals) in 22 patients was performed to evaluate FDG imaging characteristics. The impact of clinically used oxygen sensors (carbon black, charcoal particulates, LiNc-BuO microcrystals) on FDG-PET/CT imaging after implantation in rat muscle (n = 12) was investigated. The retrospective review revealed no other patients with FDG avidity associated with particulate sensors. The preclinical investigation found no injected oxygen sensor whose mean standard uptake values differed significantly from sham injections. The risk of a false-positive FDG-PET/CT scan due to oxygen sensors appears low. However, in the right clinical context the potential exists that an associated inflammatory reaction may confound interpretation.
format	article
author	Philip E. Schaner Ly-Binh-An Tran Bassem I. Zaki Harold M. Swartz Eugene Demidenko Benjamin B. Williams Alan Siegel Periannan Kuppusamy Ann Barry Flood Bernard Gallez
author_facet	Philip E. Schaner Ly-Binh-An Tran Bassem I. Zaki Harold M. Swartz Eugene Demidenko Benjamin B. Williams Alan Siegel Periannan Kuppusamy Ann Barry Flood Bernard Gallez
author_sort	Philip E. Schaner
title	The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
title_short	The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
title_full	The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
title_fullStr	The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
title_full_unstemmed	The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
title_sort	impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/64f07c0a11434748a2d9a0bd74b7764a
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The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography

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