Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota

Laurel B Tanke,1 Kevin D Chodnicki,1 Timothy W Olsen,1 M Tariq Bhatti,1,2 John J Chen1,2 1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA; 2Department of Neurology, Mayo Clinic, Rochester, MN, USACorrespondence: John J ChenDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USAEmai...

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Autores principales:	Tanke LB, Chodnicki KD, Olsen TW, Bhatti MT, Chen JJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	central retinal artery occlusion neovascular glaucoma Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/64f59573756b43e2a110929b9739629d
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spelling	oai:doaj.org-article:64f59573756b43e2a110929b9739629d2021-12-02T15:11:05ZPopulation-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota1177-5483https://doaj.org/article/64f59573756b43e2a110929b9739629d2021-08-01T00:00:00Zhttps://www.dovepress.com/population-based-incidence-of-ocular-neovascularization-following-cent-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Laurel B Tanke,1 Kevin D Chodnicki,1 Timothy W Olsen,1 M Tariq Bhatti,1,2 John J Chen1,2 1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA; 2Department of Neurology, Mayo Clinic, Rochester, MN, USACorrespondence: John J ChenDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USAEmail chen.john@mayo.eduPurpose: To determine the population-based incidence of ocular neovascularization (NV) following central retinal artery occlusion (CRAO) and systemic risk factors associated with its development.Methods: Diagnosis of CRAO between January 1, 1976, and September 9, 2016, was identified using the Rochester Epidemiology Project, a medical records linkage system for all medical care provided to residents of Olmsted County, Minnesota. Records were reviewed to confirm the diagnosis of CRAO, and data were collected on ocular NV and associated systemic diseases.Results: There were 89 patients with CRAO. Subsequent ocular neovascularization developed in 14 (16%) patients. Neovascularization of the iris (NVI) was present in 9/14 (64%) of these patients, neovascularization of the angle (NVA) in 10/14 (71%), neovascularization of the disc (NVD) in 2/14 (14%), and neovascularization elsewhere (NVE) in 1/14 (7%). Of these 14 patients with NV, 9 (64%) developed neovascular glaucoma (NVG). The mean time from CRAO diagnosis to NV was 82 days (range 22 to 268 days). Excluding the patients with proliferative diabetic retinopathy or CRAO caused by CRVO, the mean time to NV diagnosis was 80 days and the shortest time to NV diagnosis was 22 days. Diabetes mellitus was present in 64% of those with NV compared to 23% of those without NV (P = 0.003).Conclusion: The population-based incidence of ocular neovascularization following CRAO is 16% and developed within 2 months in half the cohort. Patients with diabetes mellitus are at increased risk for NV complications.Keywords: central retinal artery occlusion, neovascular glaucomaTanke LBChodnicki KDOlsen TWBhatti MTChen JJDove Medical Pressarticlecentral retinal artery occlusionneovascular glaucomaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3531-3537 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	central retinal artery occlusion neovascular glaucoma Ophthalmology RE1-994
spellingShingle	central retinal artery occlusion neovascular glaucoma Ophthalmology RE1-994 Tanke LB Chodnicki KD Olsen TW Bhatti MT Chen JJ Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
description	Laurel B Tanke,1 Kevin D Chodnicki,1 Timothy W Olsen,1 M Tariq Bhatti,1,2 John J Chen1,2 1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA; 2Department of Neurology, Mayo Clinic, Rochester, MN, USACorrespondence: John J ChenDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USAEmail chen.john@mayo.eduPurpose: To determine the population-based incidence of ocular neovascularization (NV) following central retinal artery occlusion (CRAO) and systemic risk factors associated with its development.Methods: Diagnosis of CRAO between January 1, 1976, and September 9, 2016, was identified using the Rochester Epidemiology Project, a medical records linkage system for all medical care provided to residents of Olmsted County, Minnesota. Records were reviewed to confirm the diagnosis of CRAO, and data were collected on ocular NV and associated systemic diseases.Results: There were 89 patients with CRAO. Subsequent ocular neovascularization developed in 14 (16%) patients. Neovascularization of the iris (NVI) was present in 9/14 (64%) of these patients, neovascularization of the angle (NVA) in 10/14 (71%), neovascularization of the disc (NVD) in 2/14 (14%), and neovascularization elsewhere (NVE) in 1/14 (7%). Of these 14 patients with NV, 9 (64%) developed neovascular glaucoma (NVG). The mean time from CRAO diagnosis to NV was 82 days (range 22 to 268 days). Excluding the patients with proliferative diabetic retinopathy or CRAO caused by CRVO, the mean time to NV diagnosis was 80 days and the shortest time to NV diagnosis was 22 days. Diabetes mellitus was present in 64% of those with NV compared to 23% of those without NV (P = 0.003).Conclusion: The population-based incidence of ocular neovascularization following CRAO is 16% and developed within 2 months in half the cohort. Patients with diabetes mellitus are at increased risk for NV complications.Keywords: central retinal artery occlusion, neovascular glaucoma
format	article
author	Tanke LB Chodnicki KD Olsen TW Bhatti MT Chen JJ
author_facet	Tanke LB Chodnicki KD Olsen TW Bhatti MT Chen JJ
author_sort	Tanke LB
title	Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
title_short	Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
title_full	Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
title_fullStr	Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
title_full_unstemmed	Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota
title_sort	population-based incidence of ocular neovascularization following central retinal artery occlusion in olmsted county, minnesota
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/64f59573756b43e2a110929b9739629d
work_keys_str_mv	AT tankelb populationbasedincidenceofocularneovascularizationfollowingcentralretinalarteryocclusioninolmstedcountyminnesota AT chodnickikd populationbasedincidenceofocularneovascularizationfollowingcentralretinalarteryocclusioninolmstedcountyminnesota AT olsentw populationbasedincidenceofocularneovascularizationfollowingcentralretinalarteryocclusioninolmstedcountyminnesota AT bhattimt populationbasedincidenceofocularneovascularizationfollowingcentralretinalarteryocclusioninolmstedcountyminnesota AT chenjj populationbasedincidenceofocularneovascularizationfollowingcentralretinalarteryocclusioninolmstedcountyminnesota
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Population-Based Incidence of Ocular Neovascularization Following Central Retinal Artery Occlusion in Olmsted County, Minnesota

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