Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Nrf2 is a transcriptional activator of oxidative stress response genes. Here the authors show that Nrf2 binds to promoters of proinflammatory genes and interferes with their transcriptional upregulation in LPS-stimulated macrophages independently of its role in regulation of reactive oxygen species.

Guardado en:

Detalles Bibliográficos
Autores principales:	Eri H. Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Makiko Hayashi, Hiroki Sekine, Nobuyuki Tanaka, Takashi Moriguchi, Hozumi Motohashi, Keiko Nakayama, Masayuki Yamamoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64f68c1a2df449c4a3c17e7079f6efb6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:64f68c1a2df449c4a3c17e7079f6efb6
record_format	dspace
spelling	oai:doaj.org-article:64f68c1a2df449c4a3c17e7079f6efb62021-12-02T14:38:34ZNrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription10.1038/ncomms116242041-1723https://doaj.org/article/64f68c1a2df449c4a3c17e7079f6efb62016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11624https://doaj.org/toc/2041-1723Nrf2 is a transcriptional activator of oxidative stress response genes. Here the authors show that Nrf2 binds to promoters of proinflammatory genes and interferes with their transcriptional upregulation in LPS-stimulated macrophages independently of its role in regulation of reactive oxygen species.Eri H. KobayashiTakafumi SuzukiRyo FunayamaTakeshi NagashimaMakiko HayashiHiroki SekineNobuyuki TanakaTakashi MoriguchiHozumi MotohashiKeiko NakayamaMasayuki YamamotoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eri H. Kobayashi Takafumi Suzuki Ryo Funayama Takeshi Nagashima Makiko Hayashi Hiroki Sekine Nobuyuki Tanaka Takashi Moriguchi Hozumi Motohashi Keiko Nakayama Masayuki Yamamoto Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
description	Nrf2 is a transcriptional activator of oxidative stress response genes. Here the authors show that Nrf2 binds to promoters of proinflammatory genes and interferes with their transcriptional upregulation in LPS-stimulated macrophages independently of its role in regulation of reactive oxygen species.
format	article
author	Eri H. Kobayashi Takafumi Suzuki Ryo Funayama Takeshi Nagashima Makiko Hayashi Hiroki Sekine Nobuyuki Tanaka Takashi Moriguchi Hozumi Motohashi Keiko Nakayama Masayuki Yamamoto
author_facet	Eri H. Kobayashi Takafumi Suzuki Ryo Funayama Takeshi Nagashima Makiko Hayashi Hiroki Sekine Nobuyuki Tanaka Takashi Moriguchi Hozumi Motohashi Keiko Nakayama Masayuki Yamamoto
author_sort	Eri H. Kobayashi
title	Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
title_short	Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
title_full	Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
title_fullStr	Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
title_full_unstemmed	Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
title_sort	nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/64f68c1a2df449c4a3c17e7079f6efb6
work_keys_str_mv	AT erihkobayashi nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT takafumisuzuki nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT ryofunayama nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT takeshinagashima nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT makikohayashi nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT hirokisekine nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT nobuyukitanaka nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT takashimoriguchi nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT hozumimotohashi nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT keikonakayama nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription AT masayukiyamamoto nrf2suppressesmacrophageinflammatoryresponsebyblockingproinflammatorycytokinetranscription
_version_	1718390954284548096

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Ejemplares similares