Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men

Riad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Sc...

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Autores principales: Taher R, Sara JD, Heidari B, Toya T, Lerman LO, Lerman A
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Publicado: Dove Medical Press 2019
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spelling oai:doaj.org-article:64f6b40a701d461fa1f16d97806d0d722021-12-02T05:31:56ZMetabolic syndrome is associated with peripheral endothelial dysfunction amongst men1178-7007https://doaj.org/article/64f6b40a701d461fa1f16d97806d0d722019-07-01T00:00:00Zhttps://www.dovepress.com/metabolic-syndrome-is-associated-with-peripheral-endothelial-dysfuncti-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Riad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USAPurpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index≥25 kg/m,2 impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.Results: Six hundred seventy-eight patients were included (mean age 51.9±13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.Keywords: metabolic syndrome, peripheral endothelial dysfunction, reactive hyperemia peripheral arterial tonometry, cardiovascular diseaseTaher RSara JDHeidari BToya TLerman LOLerman ADove Medical PressarticleMetabolic syndromeperipheral endothelial dysfunctionReactive Hyperemia Peripheral Arterial Tonometrycardiovascular diseaseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1035-1045 (2019)
institution DOAJ
collection DOAJ
language EN
topic Metabolic syndrome
peripheral endothelial dysfunction
Reactive Hyperemia Peripheral Arterial Tonometry
cardiovascular disease
Specialties of internal medicine
RC581-951
spellingShingle Metabolic syndrome
peripheral endothelial dysfunction
Reactive Hyperemia Peripheral Arterial Tonometry
cardiovascular disease
Specialties of internal medicine
RC581-951
Taher R
Sara JD
Heidari B
Toya T
Lerman LO
Lerman A
Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
description Riad Taher,1 Jaskanwal D Sara,1 Behnam Heidari,1 Takumi Toya,1 Lilach O Lerman,2 Amir Lerman11Division of Cardiovascular Diseases, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 2Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USAPurpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index≥25 kg/m,2 impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.Results: Six hundred seventy-eight patients were included (mean age 51.9±13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.Keywords: metabolic syndrome, peripheral endothelial dysfunction, reactive hyperemia peripheral arterial tonometry, cardiovascular disease
format article
author Taher R
Sara JD
Heidari B
Toya T
Lerman LO
Lerman A
author_facet Taher R
Sara JD
Heidari B
Toya T
Lerman LO
Lerman A
author_sort Taher R
title Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
title_short Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
title_full Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
title_fullStr Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
title_full_unstemmed Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
title_sort metabolic syndrome is associated with peripheral endothelial dysfunction amongst men
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/64f6b40a701d461fa1f16d97806d0d72
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AT heidarib metabolicsyndromeisassociatedwithperipheralendothelialdysfunctionamongstmen
AT toyat metabolicsyndromeisassociatedwithperipheralendothelialdysfunctionamongstmen
AT lermanlo metabolicsyndromeisassociatedwithperipheralendothelialdysfunctionamongstmen
AT lermana metabolicsyndromeisassociatedwithperipheralendothelialdysfunctionamongstmen
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