Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women

Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations. Aim: To evaluate the association of three polymorphic variant...

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Autores principales:	Fatima Hamad, Sulma I. Mohammed, Abdelrahim O. Mohamed, Dafalla O. Abuidris Elmustafa
Formato:	article
Lenguaje:	EN
Publicado:	AOSIS 2021
Materias:	breast cancer cyp1a1 gene polymorphisms genotype premenopausal postmenopausal sudan risk factors education Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/64f8224644424c94a33ab8becba7b3fc
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spelling	oai:doaj.org-article:64f8224644424c94a33ab8becba7b3fc2021-11-24T07:48:46ZPatients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women2518-87042523-064610.4102/sajo.v5i0.150https://doaj.org/article/64f8224644424c94a33ab8becba7b3fc2021-10-01T00:00:00Zhttps://sajo.org.za/index.php/sajo/article/view/150https://doaj.org/toc/2518-8704https://doaj.org/toc/2523-0646Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations. Aim: To evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer in Sudanese women. Sett ing: This is a case-control study. Methods: After consenting, the participants completed questionnaires consisting of sociodemographic data, gynaecological status, and breast cancer history. We recorded clinical data, weight, and height for each woman and drew blood for PCR and RFLP analyses for CYP1A1 genotyping. Results: The CYP1A1 M1 and CYP1A1 M3 genotypes and homozygous CYP1A1 M1 (C/C) and CYP1A1 M3 (C/C) genotypes are not associated with breast cancer risk and menopausal status in women. The homozygous CYP1A1 M2 (A/A) genotype had a significant association with a risk reduction of breast cancer in premenopausal women. In contrast, the heterozygous CYP1A1 M2 (A/G) and the homozygous (G/G) are associated with significant breast cancer risk. Conclusion: Despite the limitations encountered in this study that included the small sample size and availability of age-matched controls, the results suggest that the CYP1A1 M2 polymorphism, educational level, and family history of breast cancer may have an association with the risk of developing breast cancer amongst Sudanese women and warrant confirmation in more extensive studies.Fatima HamadSulma I. MohammedAbdelrahim O. MohamedDafalla O. Abuidris ElmustafaAOSISarticlebreast cancercyp1a1 genepolymorphismsgenotypepremenopausalpostmenopausalsudanrisk factorseducationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENSouth African Journal of Oncology, Vol 5, Iss 0, Pp e1-e7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer cyp1a1 gene polymorphisms genotype premenopausal postmenopausal sudan risk factors education Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer cyp1a1 gene polymorphisms genotype premenopausal postmenopausal sudan risk factors education Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fatima Hamad Sulma I. Mohammed Abdelrahim O. Mohamed Dafalla O. Abuidris Elmustafa Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
description	Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations. Aim: To evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer in Sudanese women. Sett ing: This is a case-control study. Methods: After consenting, the participants completed questionnaires consisting of sociodemographic data, gynaecological status, and breast cancer history. We recorded clinical data, weight, and height for each woman and drew blood for PCR and RFLP analyses for CYP1A1 genotyping. Results: The CYP1A1 M1 and CYP1A1 M3 genotypes and homozygous CYP1A1 M1 (C/C) and CYP1A1 M3 (C/C) genotypes are not associated with breast cancer risk and menopausal status in women. The homozygous CYP1A1 M2 (A/A) genotype had a significant association with a risk reduction of breast cancer in premenopausal women. In contrast, the heterozygous CYP1A1 M2 (A/G) and the homozygous (G/G) are associated with significant breast cancer risk. Conclusion: Despite the limitations encountered in this study that included the small sample size and availability of age-matched controls, the results suggest that the CYP1A1 M2 polymorphism, educational level, and family history of breast cancer may have an association with the risk of developing breast cancer amongst Sudanese women and warrant confirmation in more extensive studies.
format	article
author	Fatima Hamad Sulma I. Mohammed Abdelrahim O. Mohamed Dafalla O. Abuidris Elmustafa
author_facet	Fatima Hamad Sulma I. Mohammed Abdelrahim O. Mohamed Dafalla O. Abuidris Elmustafa
author_sort	Fatima Hamad
title	Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
title_short	Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
title_full	Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
title_fullStr	Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
title_full_unstemmed	Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women
title_sort	patients’ characteristics, cytochrome p4501a1 genetic polymorphisms and breast cancer risk in sudanese women
publisher	AOSIS
publishDate	2021
url	https://doaj.org/article/64f8224644424c94a33ab8becba7b3fc
work_keys_str_mv	AT fatimahamad patientscharacteristicscytochromep4501a1geneticpolymorphismsandbreastcancerriskinsudanesewomen AT sulmaimohammed patientscharacteristicscytochromep4501a1geneticpolymorphismsandbreastcancerriskinsudanesewomen AT abdelrahimomohamed patientscharacteristicscytochromep4501a1geneticpolymorphismsandbreastcancerriskinsudanesewomen AT dafallaoabuidriselmustafa patientscharacteristicscytochromep4501a1geneticpolymorphismsandbreastcancerriskinsudanesewomen
_version_	1718415861186822144

Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women

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