Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing

Progress in computational neuroscience toward understanding brain function is challenged both by the complexity of molecular-scale electrochemical interactions at the level of individual neurons and synapses and the dimensionality of network dynamics across the brain covering a vast range of spatial...

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Autores principales:	Margot Wagner, Thomas M. Bartol, Terrence J. Sejnowski, Gert Cauwenberghs
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neuromorphic synapse Markov chain Monte Carlo synaptic transmission computational efficiency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/64f8a1ae88d44d1f841ddbe9526d616e
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spelling	oai:doaj.org-article:64f8a1ae88d44d1f841ddbe9526d616e2021-12-01T13:21:05ZMarkov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing1662-453X10.3389/fnins.2021.698635https://doaj.org/article/64f8a1ae88d44d1f841ddbe9526d616e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.698635/fullhttps://doaj.org/toc/1662-453XProgress in computational neuroscience toward understanding brain function is challenged both by the complexity of molecular-scale electrochemical interactions at the level of individual neurons and synapses and the dimensionality of network dynamics across the brain covering a vast range of spatial and temporal scales. Our work abstracts an existing highly detailed, biophysically realistic 3D reaction-diffusion model of a chemical synapse to a compact internal state space representation that maps onto parallel neuromorphic hardware for efficient emulation at a very large scale and offers near-equivalence in input-output dynamics while preserving biologically interpretable tunable parameters.Margot WagnerMargot WagnerMargot WagnerThomas M. BartolThomas M. BartolTerrence J. SejnowskiTerrence J. SejnowskiTerrence J. SejnowskiTerrence J. SejnowskiTerrence J. SejnowskiGert CauwenberghsGert CauwenberghsGert CauwenberghsFrontiers Media S.A.articleneuromorphicsynapseMarkov chainMonte Carlosynaptic transmissioncomputational efficiencyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuromorphic synapse Markov chain Monte Carlo synaptic transmission computational efficiency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neuromorphic synapse Markov chain Monte Carlo synaptic transmission computational efficiency Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Margot Wagner Margot Wagner Margot Wagner Thomas M. Bartol Thomas M. Bartol Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Gert Cauwenberghs Gert Cauwenberghs Gert Cauwenberghs Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
description	Progress in computational neuroscience toward understanding brain function is challenged both by the complexity of molecular-scale electrochemical interactions at the level of individual neurons and synapses and the dimensionality of network dynamics across the brain covering a vast range of spatial and temporal scales. Our work abstracts an existing highly detailed, biophysically realistic 3D reaction-diffusion model of a chemical synapse to a compact internal state space representation that maps onto parallel neuromorphic hardware for efficient emulation at a very large scale and offers near-equivalence in input-output dynamics while preserving biologically interpretable tunable parameters.
format	article
author	Margot Wagner Margot Wagner Margot Wagner Thomas M. Bartol Thomas M. Bartol Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Gert Cauwenberghs Gert Cauwenberghs Gert Cauwenberghs
author_facet	Margot Wagner Margot Wagner Margot Wagner Thomas M. Bartol Thomas M. Bartol Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Terrence J. Sejnowski Gert Cauwenberghs Gert Cauwenberghs Gert Cauwenberghs
author_sort	Margot Wagner
title	Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
title_short	Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
title_full	Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
title_fullStr	Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
title_full_unstemmed	Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing
title_sort	markov chain abstractions of electrochemical reaction-diffusion in synaptic transmission for neuromorphic computing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/64f8a1ae88d44d1f841ddbe9526d616e
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Markov Chain Abstractions of Electrochemical Reaction-Diffusion in Synaptic Transmission for Neuromorphic Computing

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