Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers calcium signaling in the astrocyte and enhances SNAR...

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Autores principales:	Marta Navarrete, María I. Cuartero, Rocío Palenzuela, Jonathan E. Draffin, Ainoa Konomi, Irene Serra, Sandra Colié, Sergio Castaño-Castaño, Mazahir T. Hasan, Ángel R. Nebreda, José A. Esteban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64fbe2d448114949bc68acc5d6e2db61
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spelling	oai:doaj.org-article:64fbe2d448114949bc68acc5d6e2db612021-12-02T15:35:37ZAstrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory10.1038/s41467-019-10830-92041-1723https://doaj.org/article/64fbe2d448114949bc68acc5d6e2db612019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10830-9https://doaj.org/toc/2041-1723How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers calcium signaling in the astrocyte and enhances SNARE-dependent astrocytic glutamate release, which is then responsible for the activation of postsynaptic NMDA receptors and synaptic depression.Marta NavarreteMaría I. CuarteroRocío PalenzuelaJonathan E. DraffinAinoa KonomiIrene SerraSandra ColiéSergio Castaño-CastañoMazahir T. HasanÁngel R. NebredaJosé A. EstebanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Navarrete María I. Cuartero Rocío Palenzuela Jonathan E. Draffin Ainoa Konomi Irene Serra Sandra Colié Sergio Castaño-Castaño Mazahir T. Hasan Ángel R. Nebreda José A. Esteban Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
description	How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components. Here, authors show that Long-term depression (LTD) induction in the hippocampus triggers calcium signaling in the astrocyte and enhances SNARE-dependent astrocytic glutamate release, which is then responsible for the activation of postsynaptic NMDA receptors and synaptic depression.
format	article
author	Marta Navarrete María I. Cuartero Rocío Palenzuela Jonathan E. Draffin Ainoa Konomi Irene Serra Sandra Colié Sergio Castaño-Castaño Mazahir T. Hasan Ángel R. Nebreda José A. Esteban
author_facet	Marta Navarrete María I. Cuartero Rocío Palenzuela Jonathan E. Draffin Ainoa Konomi Irene Serra Sandra Colié Sergio Castaño-Castaño Mazahir T. Hasan Ángel R. Nebreda José A. Esteban
author_sort	Marta Navarrete
title	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
title_short	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
title_full	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
title_fullStr	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
title_full_unstemmed	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
title_sort	astrocytic p38α mapk drives nmda receptor-dependent long-term depression and modulates long-term memory
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/64fbe2d448114949bc68acc5d6e2db61
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Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

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