Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of th...

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Autores principales: Shuang Wang, Yun Peng, Rongjuan Wang, Shasha Jiao, Min Wang, Weijin Huang, Chao Shan, Wen Jiang, Zepeng Li, Chunying Gu, Ben Chen, Xue Hu, Yanfeng Yao, Juan Min, Huajun Zhang, Ying Chen, Ge Gao, Peipei Tang, Gang Li, An Wang, Lan Wang, Jinchao Zhang, Shuo Chen, Xun Gui, Zhiming Yuan, Datao Liu
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/64fd62f6fe674572808f71c3eaca2ed9
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spelling oai:doaj.org-article:64fd62f6fe674572808f71c3eaca2ed92021-12-02T15:39:23ZCharacterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys10.1038/s41467-020-19568-12041-1723https://doaj.org/article/64fd62f6fe674572808f71c3eaca2ed92020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19568-1https://doaj.org/toc/2041-1723Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of the antibody.Shuang WangYun PengRongjuan WangShasha JiaoMin WangWeijin HuangChao ShanWen JiangZepeng LiChunying GuBen ChenXue HuYanfeng YaoJuan MinHuajun ZhangYing ChenGe GaoPeipei TangGang LiAn WangLan WangJinchao ZhangShuo ChenXun GuiZhiming YuanDatao LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuang Wang
Yun Peng
Rongjuan Wang
Shasha Jiao
Min Wang
Weijin Huang
Chao Shan
Wen Jiang
Zepeng Li
Chunying Gu
Ben Chen
Xue Hu
Yanfeng Yao
Juan Min
Huajun Zhang
Ying Chen
Ge Gao
Peipei Tang
Gang Li
An Wang
Lan Wang
Jinchao Zhang
Shuo Chen
Xun Gui
Zhiming Yuan
Datao Liu
Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
description Here the authors characterize a monoclonal antibody from a COVID-19 convalescent patient that interferes with SARS-CoV-2 spike binding to ACE2 and has prophylactic and therapeutic activity in non-human primates. Antibody-dependent enhancement of infection is prevented by mutating the Fc region of the antibody.
format article
author Shuang Wang
Yun Peng
Rongjuan Wang
Shasha Jiao
Min Wang
Weijin Huang
Chao Shan
Wen Jiang
Zepeng Li
Chunying Gu
Ben Chen
Xue Hu
Yanfeng Yao
Juan Min
Huajun Zhang
Ying Chen
Ge Gao
Peipei Tang
Gang Li
An Wang
Lan Wang
Jinchao Zhang
Shuo Chen
Xun Gui
Zhiming Yuan
Datao Liu
author_facet Shuang Wang
Yun Peng
Rongjuan Wang
Shasha Jiao
Min Wang
Weijin Huang
Chao Shan
Wen Jiang
Zepeng Li
Chunying Gu
Ben Chen
Xue Hu
Yanfeng Yao
Juan Min
Huajun Zhang
Ying Chen
Ge Gao
Peipei Tang
Gang Li
An Wang
Lan Wang
Jinchao Zhang
Shuo Chen
Xun Gui
Zhiming Yuan
Datao Liu
author_sort Shuang Wang
title Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
title_short Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
title_full Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
title_fullStr Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
title_full_unstemmed Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
title_sort characterization of neutralizing antibody with prophylactic and therapeutic efficacy against sars-cov-2 in rhesus monkeys
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/64fd62f6fe674572808f71c3eaca2ed9
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