The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis

<i>Aspergillus fumigatus</i> is commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000–2015) that included 132 patients, we determined the annual lung functi...

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Autores principales:	Mahasin Al Shakirchi, Kimmo Sorjonen, Lena Klingspor, Peter Bergman, Lena Hjelte, Isabelle de Monestrol
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cystic fibrosis fungi <i>Aspergillus fumigatus</i> lung function Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/64fec8e4cc064f2f801d1aaaee17c276
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id	oai:doaj.org-article:64fec8e4cc064f2f801d1aaaee17c276
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spelling	oai:doaj.org-article:64fec8e4cc064f2f801d1aaaee17c2762021-11-25T18:06:01ZThe Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis10.3390/jof71109442309-608Xhttps://doaj.org/article/64fec8e4cc064f2f801d1aaaee17c2762021-11-01T00:00:00Zhttps://www.mdpi.com/2309-608X/7/11/944https://doaj.org/toc/2309-608X<i>Aspergillus fumigatus</i> is commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000–2015) that included 132 patients, we determined the annual lung function, measured as percent predicted forced expiratory volume in the first second (ppFEV1), decline before and after the first colonization with <i>A. fumigatus</i>. Further, in the same individual, the ratios of lung function when patients were colonized with <i>A. fumigatus</i> and when they were not were calculated. The impact of eradication, with antifungal treatment or spontaneously, was assessed. The annual ppFEV1 was significantly lower after the first colonization with <i>A. fumigatus</i>. Furthermore, within the same individual, colonization with <i>A. fumigatus</i> for two and three years in a row was associated with 4.3% and 7.9% lower ppFEV1, respectively, compared to when not colonized. Finally, patients who eradicated <i>A. fumigatus</i> the following two years after colonization exhibited 9.9% and 14.5% higher ppFEV1 compared to patients who continued to produce cultures with <i>A. fumigatus</i> for two and three years. Our study demonstrated that <i>A. fumigatus</i> colonization was associated with a negative impact on lung function in the long term and eradication, spontaneously or with treatment, was associated with a better pulmonary outcome.Mahasin Al ShakirchiKimmo SorjonenLena KlingsporPeter BergmanLena HjelteIsabelle de MonestrolMDPI AGarticlecystic fibrosisfungi<i>Aspergillus fumigatus</i>lung functionBiology (General)QH301-705.5ENJournal of Fungi, Vol 7, Iss 944, p 944 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cystic fibrosis fungi <i>Aspergillus fumigatus</i> lung function Biology (General) QH301-705.5
spellingShingle	cystic fibrosis fungi <i>Aspergillus fumigatus</i> lung function Biology (General) QH301-705.5 Mahasin Al Shakirchi Kimmo Sorjonen Lena Klingspor Peter Bergman Lena Hjelte Isabelle de Monestrol The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
description	<i>Aspergillus fumigatus</i> is commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000–2015) that included 132 patients, we determined the annual lung function, measured as percent predicted forced expiratory volume in the first second (ppFEV1), decline before and after the first colonization with <i>A. fumigatus</i>. Further, in the same individual, the ratios of lung function when patients were colonized with <i>A. fumigatus</i> and when they were not were calculated. The impact of eradication, with antifungal treatment or spontaneously, was assessed. The annual ppFEV1 was significantly lower after the first colonization with <i>A. fumigatus</i>. Furthermore, within the same individual, colonization with <i>A. fumigatus</i> for two and three years in a row was associated with 4.3% and 7.9% lower ppFEV1, respectively, compared to when not colonized. Finally, patients who eradicated <i>A. fumigatus</i> the following two years after colonization exhibited 9.9% and 14.5% higher ppFEV1 compared to patients who continued to produce cultures with <i>A. fumigatus</i> for two and three years. Our study demonstrated that <i>A. fumigatus</i> colonization was associated with a negative impact on lung function in the long term and eradication, spontaneously or with treatment, was associated with a better pulmonary outcome.
format	article
author	Mahasin Al Shakirchi Kimmo Sorjonen Lena Klingspor Peter Bergman Lena Hjelte Isabelle de Monestrol
author_facet	Mahasin Al Shakirchi Kimmo Sorjonen Lena Klingspor Peter Bergman Lena Hjelte Isabelle de Monestrol
author_sort	Mahasin Al Shakirchi
title	The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
title_short	The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
title_full	The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
title_fullStr	The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
title_full_unstemmed	The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis
title_sort	effects of <i>aspergillus fumigatus</i> colonization on lung function in patients with cystic fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/64fec8e4cc064f2f801d1aaaee17c276
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The Effects of <i>Aspergillus fumigatus</i> Colonization on Lung Function in Patients with Cystic Fibrosis

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