Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening microorganisms for global human health. The current strategies to reduce the impact of S. aureus include a restrictive control of worldwide antibiotic use, prophylactic measures to hinder contamination, and th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Diana Gutiérrez, Lucía Fernández, Ana Rodríguez, Pilar García
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Staphylococcus aureus bacteriophage bacteriophage therapy endolysin Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6500886d083c4e3990fcc8fc96c1bff9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6500886d083c4e3990fcc8fc96c1bff9
record_format	dspace
spelling	oai:doaj.org-article:6500886d083c4e3990fcc8fc96c1bff92021-11-15T15:53:26ZAre Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?10.1128/mBio.01923-172150-7511https://doaj.org/article/6500886d083c4e3990fcc8fc96c1bff92018-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01923-17https://doaj.org/toc/2150-7511ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening microorganisms for global human health. The current strategies to reduce the impact of S. aureus include a restrictive control of worldwide antibiotic use, prophylactic measures to hinder contamination, and the search for novel antimicrobials to treat human and animal infections caused by this bacterium. The last strategy is currently the focus of considerable research. In this regard, phage lytic proteins (endolysins and virion-associated peptidoglycan hydrolases [VAPGHs]) have been proposed as suitable candidates. Indeed, these proteins display narrow-spectrum antimicrobial activity and a virtual lack of bacterial-resistance development. Additionally, the therapeutic use of phage lytic proteins in S. aureus animal infection models is yielding promising results, showing good efficacy without apparent side effects. Nonetheless, human clinical trials are still in progress, and data are not available yet. This minireview also analyzes the main obstacles for introducing phage lytic proteins as human therapeutics against S. aureus infections. Besides the common technological problems derived from large-scale production of therapeutic proteins, a major setback is the lack of a proper legal framework regulating their use. In that sense, the relevant health authorities should urgently have a timely discussion about these new antimicrobials. On the other hand, the research community should provide data to dispel any doubts regarding their efficacy and safety. Overall, the appropriate scientific data and regulatory framework will encourage pharmaceutical companies to invest in these promising antimicrobials.Diana GutiérrezLucía FernándezAna RodríguezPilar GarcíaAmerican Society for MicrobiologyarticleStaphylococcus aureusbacteriophagebacteriophage therapyendolysinMicrobiologyQR1-502ENmBio, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Staphylococcus aureus bacteriophage bacteriophage therapy endolysin Microbiology QR1-502
spellingShingle	Staphylococcus aureus bacteriophage bacteriophage therapy endolysin Microbiology QR1-502 Diana Gutiérrez Lucía Fernández Ana Rodríguez Pilar García Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
description	ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening microorganisms for global human health. The current strategies to reduce the impact of S. aureus include a restrictive control of worldwide antibiotic use, prophylactic measures to hinder contamination, and the search for novel antimicrobials to treat human and animal infections caused by this bacterium. The last strategy is currently the focus of considerable research. In this regard, phage lytic proteins (endolysins and virion-associated peptidoglycan hydrolases [VAPGHs]) have been proposed as suitable candidates. Indeed, these proteins display narrow-spectrum antimicrobial activity and a virtual lack of bacterial-resistance development. Additionally, the therapeutic use of phage lytic proteins in S. aureus animal infection models is yielding promising results, showing good efficacy without apparent side effects. Nonetheless, human clinical trials are still in progress, and data are not available yet. This minireview also analyzes the main obstacles for introducing phage lytic proteins as human therapeutics against S. aureus infections. Besides the common technological problems derived from large-scale production of therapeutic proteins, a major setback is the lack of a proper legal framework regulating their use. In that sense, the relevant health authorities should urgently have a timely discussion about these new antimicrobials. On the other hand, the research community should provide data to dispel any doubts regarding their efficacy and safety. Overall, the appropriate scientific data and regulatory framework will encourage pharmaceutical companies to invest in these promising antimicrobials.
format	article
author	Diana Gutiérrez Lucía Fernández Ana Rodríguez Pilar García
author_facet	Diana Gutiérrez Lucía Fernández Ana Rodríguez Pilar García
author_sort	Diana Gutiérrez
title	Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
title_short	Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
title_full	Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
title_fullStr	Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
title_full_unstemmed	Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?
title_sort	are phage lytic proteins the secret weapon to kill <italic toggle="yes">staphylococcus aureus</italic>?
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/6500886d083c4e3990fcc8fc96c1bff9
work_keys_str_mv	AT dianagutierrez arephagelyticproteinsthesecretweapontokillitalictoggleyesstaphylococcusaureusitalic AT luciafernandez arephagelyticproteinsthesecretweapontokillitalictoggleyesstaphylococcusaureusitalic AT anarodriguez arephagelyticproteinsthesecretweapontokillitalictoggleyesstaphylococcusaureusitalic AT pilargarcia arephagelyticproteinsthesecretweapontokillitalictoggleyesstaphylococcusaureusitalic
_version_	1718427278993522688

Are Phage Lytic Proteins the Secret Weapon To Kill <italic toggle="yes">Staphylococcus aureus</italic>?

Ejemplares similares