Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C

Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C

Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At b...

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Autores principales: Dorin Nicolae Gheorghe, Dora Maria Popescu, Alex Salan, Mihail Virgil Boldeanu, Claudiu Marinel Ionele, Allma Pitru, Adina Turcu-Stiolica, Adrian Camen, Cristina Florescu, Ion Rogoveanu, Petra Surlin
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
periodontitis
chronic hepatitis C
non-surgical periodontal therapy
enzyme-linked immunosorbent assay
gingival fluid
pentraxin-3
Medicine
R
Acceso en línea:https://doaj.org/article/6501925ece3a487d936a11d4c573ce79
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spelling oai:doaj.org-article:6501925ece3a487d936a11d4c573ce792021-11-25T18:01:13ZNon-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C10.3390/jcm102252752077-0383https://doaj.org/article/6501925ece3a487d936a11d4c573ce792021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5275https://doaj.org/toc/2077-0383Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response.Dorin Nicolae GheorgheDora Maria PopescuAlex SalanMihail Virgil BoldeanuClaudiu Marinel IoneleAllma PitruAdina Turcu-StiolicaAdrian CamenCristina FlorescuIon RogoveanuPetra SurlinMDPI AGarticleperiodontitischronic hepatitis Cnon-surgical periodontal therapyenzyme-linked immunosorbent assaygingival fluidpentraxin-3MedicineRENJournal of Clinical Medicine, Vol 10, Iss 5275, p 5275 (2021)
institution DOAJ
collection DOAJ
language EN
topic periodontitis
chronic hepatitis C
non-surgical periodontal therapy
enzyme-linked immunosorbent assay
gingival fluid
pentraxin-3
Medicine
R
spellingShingle periodontitis
chronic hepatitis C
non-surgical periodontal therapy
enzyme-linked immunosorbent assay
gingival fluid
pentraxin-3
Medicine
R
Dorin Nicolae Gheorghe
Dora Maria Popescu
Alex Salan
Mihail Virgil Boldeanu
Claudiu Marinel Ionele
Allma Pitru
Adina Turcu-Stiolica
Adrian Camen
Cristina Florescu
Ion Rogoveanu
Petra Surlin
Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
description Non-surgical periodontal therapy (NSPT) is the first essential step for the management of any periodontitis patient. This study aims to evaluate the impact of NSPT on pro-inflammatory mediators’ regulation and on clinical parameters in periodontitis patients who suffer from chronic hepatitis C. At baseline, selected patients were clinically evaluated for their periodontal status. A subsequent quantitative assessment of C-reactive protein and pentraxin-3 in samples of gingival fluid was performed by Enzyme-Linked Immunosorbent Assay (ELISA). Afterwards, NSPT was performed. Three months after NSPT, the clinical and ELISA assessments were repeated. The results show an improvement of the clinical parameters in periodontitis patients at the three-month recall. In chronic hepatitis C patients with periodontitis, the gingival fluid levels of pro-inflammatory markers reduced significantly. The targeted markers also expressed significant correlations with the clinical parameters used for the assessment of periodontitis’ severity. The results suggest that, while chronic hepatitis C patients exhibited a more negative periodontal status at baseline as compared to non-hepatitis ones, NSPT is effective in decreasing the local periodontal inflammatory reaction and in proving the periodontal status of this type of patients. Given the limitation of the study, periodontal screening and NSPT should be included in the integrated therapeutical approach of chronic hepatitis C patients, for its impact on the local inflammatory response.
format article
author Dorin Nicolae Gheorghe
Dora Maria Popescu
Alex Salan
Mihail Virgil Boldeanu
Claudiu Marinel Ionele
Allma Pitru
Adina Turcu-Stiolica
Adrian Camen
Cristina Florescu
Ion Rogoveanu
Petra Surlin
author_facet Dorin Nicolae Gheorghe
Dora Maria Popescu
Alex Salan
Mihail Virgil Boldeanu
Claudiu Marinel Ionele
Allma Pitru
Adina Turcu-Stiolica
Adrian Camen
Cristina Florescu
Ion Rogoveanu
Petra Surlin
author_sort Dorin Nicolae Gheorghe
title Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_short Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_full Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_fullStr Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_full_unstemmed Non-Surgical Periodontal Therapy Could Improve the Periodontal Inflammatory Status in Patients with Periodontitis and Chronic Hepatitis C
title_sort non-surgical periodontal therapy could improve the periodontal inflammatory status in patients with periodontitis and chronic hepatitis c
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/6501925ece3a487d936a11d4c573ce79
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