In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, the authors use phosphoproteomics to define kinases with distinct activity profiles in TNBC, demonstrating their prognostic value as well as their utility for simplifying TNBC classification and designing drug regime...
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Nature Portfolio
2018
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oai:doaj.org-article:6508e17c6fdd4f1a8cecab535185385a2021-12-02T14:38:53ZIn vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer10.1038/s41467-018-05742-z2041-1723https://doaj.org/article/6508e17c6fdd4f1a8cecab535185385a2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05742-zhttps://doaj.org/toc/2041-1723Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, the authors use phosphoproteomics to define kinases with distinct activity profiles in TNBC, demonstrating their prognostic value as well as their utility for simplifying TNBC classification and designing drug regimens.Ivana ZagoracSara Fernandez-GaiteroRenske PenningHarm PostMaria J. BuenoSilvana MouronLuis MansoManuel M. MorenteSoledad AlonsoVioleta SerraJavier MuñozGonzalo Gómez-LópezJose Francisco Lopez-AcostaVeronica Jimenez-RenardAlbert Gris-OliverFatima Al-ShahrourElena Piñeiro-YañezJose Luis Montoya-SuarezJuan V. ApalaAmalia Moreno-TorresRamon ColomerAna DopazoAlbert J. R. HeckMaarten AltelaarMiguel Quintela-FandinoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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Science Q Ivana Zagorac Sara Fernandez-Gaitero Renske Penning Harm Post Maria J. Bueno Silvana Mouron Luis Manso Manuel M. Morente Soledad Alonso Violeta Serra Javier Muñoz Gonzalo Gómez-López Jose Francisco Lopez-Acosta Veronica Jimenez-Renard Albert Gris-Oliver Fatima Al-Shahrour Elena Piñeiro-Yañez Jose Luis Montoya-Suarez Juan V. Apala Amalia Moreno-Torres Ramon Colomer Ana Dopazo Albert J. R. Heck Maarten Altelaar Miguel Quintela-Fandino In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| description |
Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, the authors use phosphoproteomics to define kinases with distinct activity profiles in TNBC, demonstrating their prognostic value as well as their utility for simplifying TNBC classification and designing drug regimens. |
| format |
article |
| author |
Ivana Zagorac Sara Fernandez-Gaitero Renske Penning Harm Post Maria J. Bueno Silvana Mouron Luis Manso Manuel M. Morente Soledad Alonso Violeta Serra Javier Muñoz Gonzalo Gómez-López Jose Francisco Lopez-Acosta Veronica Jimenez-Renard Albert Gris-Oliver Fatima Al-Shahrour Elena Piñeiro-Yañez Jose Luis Montoya-Suarez Juan V. Apala Amalia Moreno-Torres Ramon Colomer Ana Dopazo Albert J. R. Heck Maarten Altelaar Miguel Quintela-Fandino |
| author_facet |
Ivana Zagorac Sara Fernandez-Gaitero Renske Penning Harm Post Maria J. Bueno Silvana Mouron Luis Manso Manuel M. Morente Soledad Alonso Violeta Serra Javier Muñoz Gonzalo Gómez-López Jose Francisco Lopez-Acosta Veronica Jimenez-Renard Albert Gris-Oliver Fatima Al-Shahrour Elena Piñeiro-Yañez Jose Luis Montoya-Suarez Juan V. Apala Amalia Moreno-Torres Ramon Colomer Ana Dopazo Albert J. R. Heck Maarten Altelaar Miguel Quintela-Fandino |
| author_sort |
Ivana Zagorac |
| title |
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| title_short |
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| title_full |
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| title_fullStr |
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| title_full_unstemmed |
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| title_sort |
in vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/6508e17c6fdd4f1a8cecab535185385a |
| work_keys_str_mv |
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