Single amino acid utilization for bacterial categorization

Abstract Despite great advancement in genetic typing, phenotyping is still an indispensable tool for categorization of bacteria. Certain amino acids may be essential for bacterial survival, growth, pathogenicity or toxin production, which prompts the idea that the intrinsic ability to utilize single...

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Autores principales:	Yi-Kai Liu, Hung-Chih Kuo, Chih-Ho Lai, Chi-Chung Chou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/650df45cd97540d7a6e00108736316f1
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spelling	oai:doaj.org-article:650df45cd97540d7a6e00108736316f12021-12-02T16:06:40ZSingle amino acid utilization for bacterial categorization10.1038/s41598-020-69686-52045-2322https://doaj.org/article/650df45cd97540d7a6e00108736316f12020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69686-5https://doaj.org/toc/2045-2322Abstract Despite great advancement in genetic typing, phenotyping is still an indispensable tool for categorization of bacteria. Certain amino acids may be essential for bacterial survival, growth, pathogenicity or toxin production, which prompts the idea that the intrinsic ability to utilize single amino acid under live-or-die situation could be a basis for differentiation of bacteria species. In this study, we determined the single amino acid consumption profiles of 7 bacterial species, and demonstrated that most bacteria have species-specific pattern of amino acid consumption. We also discovered that bacterial strains from different hosts, toxigenicity, and antibiotic-resistance presented distinct preference for certain amino acids. Taken altogether, the amino acid consumption profiles showed potential to be a novel tool complementary to study not only bacterial categorization but also biochemical characteristics of the bacteria such that its phenotyping can be used to uncover strategies for nutritional, pharmaceutical, taxonomic, and evolutionary aspects of bacterial researches.Yi-Kai LiuHung-Chih KuoChih-Ho LaiChi-Chung ChouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Kai Liu Hung-Chih Kuo Chih-Ho Lai Chi-Chung Chou Single amino acid utilization for bacterial categorization
description	Abstract Despite great advancement in genetic typing, phenotyping is still an indispensable tool for categorization of bacteria. Certain amino acids may be essential for bacterial survival, growth, pathogenicity or toxin production, which prompts the idea that the intrinsic ability to utilize single amino acid under live-or-die situation could be a basis for differentiation of bacteria species. In this study, we determined the single amino acid consumption profiles of 7 bacterial species, and demonstrated that most bacteria have species-specific pattern of amino acid consumption. We also discovered that bacterial strains from different hosts, toxigenicity, and antibiotic-resistance presented distinct preference for certain amino acids. Taken altogether, the amino acid consumption profiles showed potential to be a novel tool complementary to study not only bacterial categorization but also biochemical characteristics of the bacteria such that its phenotyping can be used to uncover strategies for nutritional, pharmaceutical, taxonomic, and evolutionary aspects of bacterial researches.
format	article
author	Yi-Kai Liu Hung-Chih Kuo Chih-Ho Lai Chi-Chung Chou
author_facet	Yi-Kai Liu Hung-Chih Kuo Chih-Ho Lai Chi-Chung Chou
author_sort	Yi-Kai Liu
title	Single amino acid utilization for bacterial categorization
title_short	Single amino acid utilization for bacterial categorization
title_full	Single amino acid utilization for bacterial categorization
title_fullStr	Single amino acid utilization for bacterial categorization
title_full_unstemmed	Single amino acid utilization for bacterial categorization
title_sort	single amino acid utilization for bacterial categorization
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/650df45cd97540d7a6e00108736316f1
work_keys_str_mv	AT yikailiu singleaminoacidutilizationforbacterialcategorization AT hungchihkuo singleaminoacidutilizationforbacterialcategorization AT chihholai singleaminoacidutilizationforbacterialcategorization AT chichungchou singleaminoacidutilizationforbacterialcategorization
_version_	1718384906388635648

Single amino acid utilization for bacterial categorization

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