A unified model of human hemoglobin switching through single-cell genome editing
Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute to HbF expression.
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Nature Portfolio
2021
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oai:doaj.org-article:6510aaea4b7a4bf494e21f0d26b79c2e2021-12-02T15:10:51ZA unified model of human hemoglobin switching through single-cell genome editing10.1038/s41467-021-25298-92041-1723https://doaj.org/article/6510aaea4b7a4bf494e21f0d26b79c2e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25298-9https://doaj.org/toc/2041-1723Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute to HbF expression.Yong ShenJeffrey M. VerboonYuannyu ZhangNan LiuYoon Jung KimSamantha MarglousSatish K. NandakumarRichard A. VoitClaudia FioriniAyesha EjazAnindita BasakStuart H. OrkinJian XuVijay G. SankaranNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yong Shen Jeffrey M. Verboon Yuannyu Zhang Nan Liu Yoon Jung Kim Samantha Marglous Satish K. Nandakumar Richard A. Voit Claudia Fiorini Ayesha Ejaz Anindita Basak Stuart H. Orkin Jian Xu Vijay G. Sankaran A unified model of human hemoglobin switching through single-cell genome editing |
| description |
Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute to HbF expression. |
| format |
article |
| author |
Yong Shen Jeffrey M. Verboon Yuannyu Zhang Nan Liu Yoon Jung Kim Samantha Marglous Satish K. Nandakumar Richard A. Voit Claudia Fiorini Ayesha Ejaz Anindita Basak Stuart H. Orkin Jian Xu Vijay G. Sankaran |
| author_facet |
Yong Shen Jeffrey M. Verboon Yuannyu Zhang Nan Liu Yoon Jung Kim Samantha Marglous Satish K. Nandakumar Richard A. Voit Claudia Fiorini Ayesha Ejaz Anindita Basak Stuart H. Orkin Jian Xu Vijay G. Sankaran |
| author_sort |
Yong Shen |
| title |
A unified model of human hemoglobin switching through single-cell genome editing |
| title_short |
A unified model of human hemoglobin switching through single-cell genome editing |
| title_full |
A unified model of human hemoglobin switching through single-cell genome editing |
| title_fullStr |
A unified model of human hemoglobin switching through single-cell genome editing |
| title_full_unstemmed |
A unified model of human hemoglobin switching through single-cell genome editing |
| title_sort |
unified model of human hemoglobin switching through single-cell genome editing |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6510aaea4b7a4bf494e21f0d26b79c2e |
| work_keys_str_mv |
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