ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in...

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Autores principales:	Jie Wang, Cristina Zibetti, Peng Shang, Srinivasa R. Sripathi, Pingwu Zhang, Marisol Cano, Thanh Hoang, Shuli Xia, Hongkai Ji, Shannath L. Merbs, Donald J. Zack, James T. Handa, Debasish Sinha, Seth Blackshaw, Jiang Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6511f6f3f7754ce6afd7e7628e525028
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spelling	oai:doaj.org-article:6511f6f3f7754ce6afd7e7628e5250282021-12-02T15:33:42ZATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration10.1038/s41467-018-03856-y2041-1723https://doaj.org/article/6511f6f3f7754ce6afd7e7628e5250282018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03856-yhttps://doaj.org/toc/2041-1723Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in AMDJie WangCristina ZibettiPeng ShangSrinivasa R. SripathiPingwu ZhangMarisol CanoThanh HoangShuli XiaHongkai JiShannath L. MerbsDonald J. ZackJames T. HandaDebasish SinhaSeth BlackshawJiang QianNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Wang Cristina Zibetti Peng Shang Srinivasa R. Sripathi Pingwu Zhang Marisol Cano Thanh Hoang Shuli Xia Hongkai Ji Shannath L. Merbs Donald J. Zack James T. Handa Debasish Sinha Seth Blackshaw Jiang Qian ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
description	Age-related macular degeneration (AMD) leads to dysfunctional retinal pigment epithelium (RPE) and vision loss. Here, the authors perform ATAC-seq to study chromatin accessibility and find that differentially accessible regions are enriched for photoreceptor and RPE-specific transcription factors in AMD
format	article
author	Jie Wang Cristina Zibetti Peng Shang Srinivasa R. Sripathi Pingwu Zhang Marisol Cano Thanh Hoang Shuli Xia Hongkai Ji Shannath L. Merbs Donald J. Zack James T. Handa Debasish Sinha Seth Blackshaw Jiang Qian
author_facet	Jie Wang Cristina Zibetti Peng Shang Srinivasa R. Sripathi Pingwu Zhang Marisol Cano Thanh Hoang Shuli Xia Hongkai Ji Shannath L. Merbs Donald J. Zack James T. Handa Debasish Sinha Seth Blackshaw Jiang Qian
author_sort	Jie Wang
title	ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
title_short	ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
title_full	ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
title_fullStr	ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
title_full_unstemmed	ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
title_sort	atac-seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6511f6f3f7754ce6afd7e7628e525028
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ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration

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